Date Posted: Mar 30, 2019
Application Deadline: Open Until Filled
- University of Miami
- Location: Miami, FL
- Job Number: 7056677 (Ref #: R100030669)
- Posting Date: Mar 30, 2019
- Application Deadline:
Open Until Filled
The Department of Dermatology at the University of Miami, Miller School of Medicine has an exciting opportunity for a Postdoctoral Associate. The Postdoctoral Associate is responsible for performing research activities and experiments in the laboratory on several aspects of cancer biology with a focus on melanoma. Several projects are ongoing in the laboratory including: 1) deciphering the role of the tumor microenvironment, specifically of immune responses triggered by the tumor; 2) understanding the role of Notch and ERBB signaling in melanoma growth and progression; 3) understanding the role of metalloproteinases in DNA repair processes. The principle models used in the laboratory include a vast array of cancer cell lines, human tumor tissues and mouse models. Projects will entail manipulation of gene expression using both RNAi and CRISPR/cas9 in conjunction with cell culture, biochemical and in vivo assays (orthotopic, xenograft and transgenic mouse models). The incumbent will assist the Principal Investigator and ensure that all experiments are appropriately conducted following the policies and procedures of the University of Miami.
Ph.D. or other doctoral-level degree in a relevant field of study or M.D. Possess a strong background in metabolism and cancer metabolism, molecular biology, cell biology, mouse genetics and have published in internationally recognized journals. Expertise in metabolism and cancer metabolism is a plus. Possess advance knowledge and capability to exercise independent judgment when carrying out research activities and performing non-routine and complex laboratory projects. Ability to perform basic cell and molecular biology techniques (cell culture of immortalized, cancer and normal cells; preparation of normal cells from animal tissues; analysis of immune cells by FACS; functional assays for immune cells; DNA and RNA extraction; PCR, RT-PCR; survival in vitro assays; viability assay; western blotting). Ability to handle small animals including tail tipping for genotyping. Ability to inoculate tumor cells into mice in the form of subcutaneous inoculation. Ability to extract immune cells and prepare them for analysis and/or further assays. Excellent verbal and written communication skills and interpersonal skills. Strong organization skills; ability to multi-task, prioritize and meet deadlines. Must demonstrate attention to detail and accuracy, time management skills, and follow-through. Ability to work effectively independently and collaboratively within a team. Must be highly motivated, responsible, dependable and a self-starter. Proficiency in Microsoft Office (ex: Word, Excel, PowerPoint), knowledge of statistical software, array analysis software preferred. Must demonstrate willingness to learn new techniques, procedures, processes, and computer programs as needed. Experience with Immunohistochemical staining preferred. Experience with microarray data analysis preferred. High attention to detail. Effective interpersonal skills.
UHealth-University of Miami Health System, South Florida's only university-based health system, provides leading-edge patient care powered by the ground breaking research and medical education at the Miller School of Medicine. As an academic medical center, we are proud to serve South Florida, Latin America and the Caribbean. Our physicians represent more than 100 specialties and sub-specialties, and have more than one million patient encounters each year. Our tradition of excellence has earned worldwide recognition for outstanding teaching, research and patient care. We're the challenge you've been looking for.
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