The overarching goal of our research program is to better understand the molecular and cellular mechanisms underlying disease progression and drug resistance in hematological malignancies. Our group is interested in studying oncogenic signaling pathways and metabolic reprogramming in hematological malignancies. We aim to uncover previously unrecognized vulnerabilities for therapeutic intervention. Our research involves multi-disciplinary approaches including molecular biology, biochemistry, chemical biology, immunology, mouse genetics and CRISPR-based gene editing. Recent relevant papers include Chan et al. Nature 2017 (doi: 10.1038/nature21076) and Chan et al. Nature 2020 (doi: 10.1038/s41586-020-2513-4). In the laboratory, we strive to promote a culture of inclusivity and provide mentorship on scientific growth and career development. The principal investigator will meet with the postdoc on a regular basis to review data, discuss goals and provide feedback and advice. 

Principal Investigator: Lai (Linda) Chan, PhD

Lerner Research Institute Department: Cancer Biology

Lab Research Topics:

• Cancer signaling pathways
• Metabolism
• Cancer Biology
• Hematological malignancies
• For more information about the lab’s research, please contact Lai (Linda) Chan at [email protected]

Job Responsibilities:

• Independent project design with the goal of data generation, analysis, interpretation and manuscript preparation
• Lead independent research projects
• Report progress and track deliverables
• Participate in teamwork and discussions
• Help train and mentor junior staff

Education:

• PhD or MD/PhD required
• MD with relevant laboratory experience may substitute for PhD

Languages:

• English Proficiency proof required for candidates arriving on J-1, J-2, or F1 + OPT visa status

Work Experience:

• Previous experience in a research or academic setting.  Graduate student experience meets this requirement.
• Scientific writing experience

Additional Preferred Qualities:

• Applicants should have recently obtained their PhD or expect to do so in the near future
• Applicants should have a background in cell and molecular biology or related fields
• Experience in cell culture and basic biochemical and molecule biology techniques is required
• Experience in mouse experiments, CRISPR and/or flow cytometry is preferred
• Strong oral and written communication skills are required

Personal Protective Equipment:

• PPE per institutional requirements; may vary by laboratory

Preferred Application Materials:

All application materials should be submitted directly via email to Lai (Linda) Chan at [email protected].

• CV
• Cover letter with contact information for three references

Keywords: Postdoc, Research, LRI