Date Posted: Oct 10, 2018
The primary purpose of the Postdoctoral Fellow is to provide support for our correlation studies for our clinical trials conducted at the Department of Investigational Cancer Therapeutics. Perform image analysis and interpretation, help with evaluation and validation of H&Es, IHC, IF, IMC and other stains. Support our laboratory with expertise in tissue evaluation, tissue handling and staining, cell line work and support with other tasks that might occur.
Our laboratory is focused on new predictive and prognostic biomarkers with emphasis in antibody-based therapies, immuno-oncology and pre-clinical studies.
• Courtesy: Is respectful and courteous to each other at all times
• Friendliness/Teamwork: Promotes and rewards teamwork and inclusiveness; Is sensitive to the concerns of our patients and our co-workers
• Reliability: Communicates frequently, honestly and openly
• Accountability: Holds self and others accountable for practicing our values
• Safety: Notices a safety concern and brings it to someone’s attention; Models safe behaviors (wears badge, washes hands, keeps work area clean and orderly); Mitigates risk to the institution through sound business practices
• Responsiveness: By his/her actions, creates an environment of trust; Encourages learning, creativity and new ideas
• Personal Leadership/Self-Initiative: Helps others to identify and solve problems; Seeks personal growth and enables others to do so.
1. To perform:
- Immunohistochemistry (IHC), in situ hybridization, mass spectrometry and other methods.
- Evaluate and validate antibody protocols for e.g. IHC, in situ hybridization methods, mass spectrometry, and other staining or procedures.
- Image analysis of formalin fixed and paraffin embedded tissues with different image analysis systems.
- Apply different image analysis software for different stains and create suitable algorithms for biomarker analysis.
- Analyze and interpret the results obtained by the image software.
- Supervise image analysis of other laboratory personnel.
- Perform annotations e.g. for tissue microarray (TMA) construction, or tumor content, etc.
- Evaluation of different tissue formats such as e. g. whole tissue sections, TMAs, etc.
- Enter the data from tissue quality control and image analysis results in dedicated databases and maintain the databases
- Assist in coordinating the logistics with study material (internally and/or externally collaborators).
- Preparing reports on image analysis results together with the investigator, and/or collaborators.
- Maintain cell line cultures, harvesting cell lines and process cell line further e.g. paraffin embedding.
- Paraffin embedding of PDX tissues/tumors.
- Select and evaluate suitable tissues for TMA construction.
- Put together blocks and slides for TMA construction.
- Make files for TMAs.
- Help with other task that might occur.
2. To assist with:
- Troubleshooting of protocols/assays.
- Selection of suitable antibodies for different specimens and different applications (e.g. IHC, immune fluorescence (IF), western blot (WB), and others.
- Finding suitable controls for different assays such as e.g. cell lines for IHC, etc.
- Logistics such as e.g. ordering antibodies, data entry into databases, etc.
- Extract clinic-pathological data from different sources e.g. databases or collaborator reports.
- Implementation of new biomarkers for tissue based detection
- Putting together data files for further analysis
- Enter results timely and accurately in databases and maintain database
- Perform simple statistical analysis.
- Preparing data for scientific reports, abstracts, manuscripts, SOPs, etc.
- TMA construction.
- Assist with other tasks that might occur.
3. To learn and assist with:
- Special tissue bases techniques such as IHC, IF, in situ methods, etc.
- Learn to perform and interpret IHC, IF, mass spectrometry and other stains/staining procedures.
- Learn to compose a TMA map and corresponding file.
- Learn image software applications.
- Learn to use different image analysis software.
- Learn how to use different databases.
- Learn how to order supplies.
- Learn cell line culture work.
- Learn to perform simple statistical analysis.
- Learn other techniques or tasks as needed.
- Learn other tasks that might occur.
4. To maintain a high level of professional expertise and credibility through educational programs,
including on-site training / off-site conferences:
– Attend department research meetings and conferences.
– Attend approved off-site meetings and conferences.
– Supplement education as needed through use of reference materials, lectures, etc.
– Be punctual in arriving at all professional functions.
– Inform appropriate staff and arrange coverage for experiments if needed.
5. To assist with development of and maintaining databases:
– Generate documents on computer, using word, excel spreadsheets, and other software
– Communicate with appropriate individual(s) regarding upcoming deadlines, meetings, etc.
6. Other duties and assignments:
– To assist with other duties that may occur (e.g. learn new techniques, etc.)
– Understand and adhere to the policies and procedures related to conduct of clinical trials and human tissue as delineated in the department training manual and the institution policies and guidelines
The performance for all expected outcomes is measured by observation by supervisor, faculty and co-workers, the accuracy and timeliness of work produced, and the demonstrated ability to effectively work under stress. The position also requires one to anticipate needs, to recognize situations requiring assistance and have the ability to refer or perform any necessary tasks, and to comprehend the goals of the department/program.
The above functions require the following abilities and skills:
• Knowledge of histology
• Ability to practice independently, strong verbal and written communication skills, organizational and critical judgment skills, and ability to interact effectively with co-workers.
• Strong attention to detail.
• Strong organizational skills.
• Ability to work with personal computers using standard word processing software, spreadsheets, and programs for database and graphics usage.
• English language, including spelling, writing, and verbalizing and ability to communicate well verbally and in writing.
• Flexibility and multitasking
• IC – Team with Others:
o Encourage collaboration and input from all team members;
o Value the contributions of all team members; and
o Balance individual and team goals
• IC – Self-Motivation:
o Set high standards of performance;
o Pursue goals with energy and persistence; and
o Drive for results and achievement.
• IC – Oral Communication:
o Express ideas clearly and concisely in groups and one-to-one conversations; and
o Create an environment with open channels of communication.
Required: MD or DVM (doctor of veterinary Medicine) with minimum one year experience in pathology
Preferred: Research experience, experience with image analysis
Required: Minimum one year experience in pathology
This position requires:
Working in Office Environment No X Yes
Working in Patient Care Unit (e.g. Nursing unit; outpatient clinic) No X Yes
Exposure to human/animal blood, body fluids, or tissues No X Yes
Exposure to harmful chemicals X No Yes
Exposure to radiation X No Yes
Exposure to animals X No Yes
Indicate the time required to do each of the following physical demands:
Up to 10 lbs X
10lbs to 50 lbs X
More than 50 lbs X
Up to 10 lbs X
10lbs to 50 lbs X
More than 50 lbs X
Use computer/keyboard X
CAN BE SEND TO: CTAPIA1@MDANDERSON.ORG
M. D. Anderson Cancer Center is an equal opportunity employer and does not discriminate on basis of race, color, national origin, gender, sexual orientation, age, religion, disability or veteran status except where such distinction is required by law. All positions at The University of Texas M. D. Anderson Cancer Center are security sensitive and subject to examination of criminal history record information. Smoke-free and drug-free environment.