Date Posted: Dec 18, 2018
Application Deadline: Jan 17, 2019
- Baylor College of Medicine
- Location: Houston, TX
- Job Number: 7054913 (Ref #: 216060SV)
- Posting Date: Dec 18, 2018
- Application Deadline:
Jan 17, 2019
The Department of Medicine provides ideal environment for pre-clinical and basic science research. This work thus has potential implications in miRNA-based therapeutics in lung disease.
This person will participate in funded research projects regarding the therapeutic utility of let-7 microRNA in tempering immune inflammation in chronic obstructive pulmonary disease (COPD) in transgenic mouse models.
Design and conduct experiments in broad areas such as cell biology, immunology, AAV/lentiviral gene therapy, and genomics approaches using mouse disease models of the lung and human lung specimens.
Develop strategies for studying the efficacy of disrupting let-7 microRNA via knockouts or CRISPR gene editing cells within the lung to reverse the impact of injury post-cigarette smoking or nano-sized carbon black.
Collect, perform data analysis, and will be proficient in basic research methods including cell sorting/flow cytometry, cloning, gene expression techniques (qPCR, Western blots), handling of mice colonies, and primary culture of CD4+ T cells and dendritic cells.
Present data at local and national meetings, mentor graduate students, and serve as co-author on publications.
PhD or MD/PhD in biological science.
Resume and First author publication(s). No more than 3 years following completion of PhD. At least one first author paper from PhD work.
Fundamental understanding of the molecular pathophysiology of Th17-driven inflammation in COPD as well as expertise in the miRNA mediated gene silencing, and lung stem cell biology.
Strong graduate background in cellular/molecular biology, Th17 tissue inflammation, immunology, and microRNAs.
Applicants with previous experience working with mice and the lung will be favorably considered.
Interested individuals should apply for this position online and also email a cover letter, curriculum vitae, and 2-3 letters of reference to: Antony Rodriguez (email@example.com).
Baylor College of Medicine is an Equal Opportunity /Affirmative Action/Equal Access Employer.
Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.