A Postdoctoral Associate position is available in a laboratory interested in the role of glycosylation and deglycosylation in animal development and human disease. The lab uses cell culture, Drosophila and mouse genetics to identify and characterize genetic modifiers of human disease genes, in hopes of shedding light on disease pathophysiology and establishing new therapeutic targets. The lab staff closely collaborate with experts in carbohydrate biochemistry. The lab has reported a mouse model for a developmental disorder called Alagille syndrome (ALGS; OMIM 118450), and identified a glycosyltransferase called Poglut1 as a dominant genetic suppressor of the biliary phenotypes in this ALGS model (Thakurdas et al, Hepatology, 2016). Have also identified a transcription factor as a dominant modifier of the disease phenotypes, whose expression also shows a strong correlation with liver disease severity in human patients (unpublished data).
Required: PhD in biomedical science or equivalent