Our lab aims to understand how cells repair damage to their DNA and how deficiency in this process results in genome instability, cancer, hereditary disorders, infertility and aging. We are particularly interested in how cells repair chromosomal double-strand breaks, one of the most dangerous types of DNA lesions. Our laboratory employs both budding and fission yeast which share a high degree of similarity with many biological processes in human cells. These model organisms provide numerous diverse experimental advantages including genetic, molecular, functional genomics, and next generation sequencing-based approaches for screening and characterizing new DNA repair proteins. We can successfully use yeast to decipher the exact mechanism of genome instability, a strategy that is not possible in other organisms due to the lack of cellular approaches.
The applicant should be familiar with microbiology, molecular biology, and aim to develop a groundbreaking study that will propel them to their own independent position, and aspire to be a leader in their field. Strong analytical and writing skills are desired.