Postdoctoral Research Scientist (Electrophysiology)
- Columbia University Department of Surgery
- Location: New York, NY
- Job Number: 7064870
- Posting Date: Feb 24, 2020
Job DescriptionThe Division of Surgical Science at Columbia University Vagelos College of Physicians and Surgeons is accepting applications for a Postdoctoral Research Scientist. The individual must be highly motivated and productive researcher who can perform independent research associated with assessment of synaptic function and transmission, synaptic vesicle biology, neurophysiology, and brain circuit structure-function analysis. The primary focus of our research is to elucidate cellular and molecular mechanisms of neurodegeneration and to develop small molecules for translational research. Candidate must have extensively experience with neurophysiology and electrophysiology and perform patch for pre- and post-synaptic transmission, long-term potentiation in vitro and in vivo animal model, and brain circuit analysis.
Requirements: PhD, MD or both. Experience in Biological Sciences, have at least two-year research experiences in the neurophysiology and electrophysiology and/or cell biology in vitro and in vivo. Strong skills in major biochemistry and cell biology techniques, animal handling, brain injection, primary cultures and quantitative data analysis related to neurophysiology. The ability to work independently after a short training period and at least 2-3 publications related to neurophysiology related to synaptic degeneration and synaptic transmission.
Responsibilities of the individual will include: 1) Perform of laboratory research in the area of synaptic degeneration relevant to neurodegeneration, synaptogenesis, using human disease mouse model including Alzheimer’s disease, diabetes, and aging, analysis of synaptic structure and function in vitro and in vivo. 2) Perform electrophysiology in brain slices, recording synaptic transmission including long-term potentiation (LTP), patch in neurons in vitro and in vivo transgenic mice. 3) Perform primary neuronal culture, analysis of pre- and post-synaptic function, quantification of synaptic density. 4) Neurophysiology and electrophysiology, animal brain in vitro neuron and vivo image and recording, animal brain surgery, and basic molecular and cellular biology including immunoblotting, immunostaining, confocal images, neuronal culture. Perform virus infect to neuron in vitro and in vivo human disease mouse model. Evaluate the effects of small molecule compounds on synaptic function and morphology alterations 5) Perform literature searches, manage data, analyze experimental results and published data and to write manuscript reporting research funding. Participate to the development of an extramurally funded research program by assisting PIs with NIH grants by developing and generating data and figures.
Columbia University is an Equal Opportunity Employer / Disability / Veteran