Postdoctoral Fellow - Molecular Diagnostics and Experimental Therapeutics
- City of Hope
- Location: California, CA
- Job Number: 7067038 (Ref #: 10006617)
- Posting Date: Jun 18, 2020
- Application Deadline: Open Until Filled
Job DescriptionAbout City of Hope
City of Hope, an innovative biomedical research, treatment and educational institution with over 6,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.
Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s leading cancer centers that develops and institutes standards of care for cancer treatment.
We are seeking a talented and motivated Postdoctoral Fellow to become a part of the multidisciplinary research team headed by Dr. Ajay Goel, who recently relocated to the City of Hope. His research is highly focused on understanding the interplay between genetic and epigenetic alterations in colorectal, pancreatic, gastric and esophageal cancers. One of the primary translational research goals is to develop novel diagnostic, prognostic, and predictive biomarkers for various gastrointestinal cancers, as well as study immune regulation and identify novel therapeutic targets (e.g. targeted therapies, immune checkpoint inhibitors) for various GI malignancies. Our multidisciplinary research group comprises of basic biologists, gastroenterologists, surgeons, oncologists and bioinformaticians, undertaking a number of collaborative projects involving large international consortia.
Key Responsibilities include:
- Exploration of cell-free and circulating DNA-based, liquid biopsy biomarkers for the early-detection of gastrointestinal cancers (including colorectal, pancreatic, gastric, liver and esophageal).
- Establish innovative methodologies involving non-coding RNAs-based biomarkers for the earlier diagnosis, prognosis and predictive responses to chemotherapy in gastrointestinal neoplasia.
- Study the role of aberrant DNA methylation, histone modifications and non-coding RNAs (miRNA, lncRNAs, snoRNAs, piRNAs etc.) in various GI malignancies.
- Understanding the genetic basis of early-onset and familial/hereditary colorectal cancers
- Molecular mechanisms of cancer pathogenesis, the role of stem cells in the context of chemo resistance chemo-sensitization in cancer cells.
- The role of tumor microenvironment, immune regulation and identification of various targeted therapies (e.g. immune checkpoint inhibitors) in GI cancers.
- The role of exosomes as biological determinants, and exosomal cargo as disease biomarkers
- Gut microbiome and its influence in gastrointestinal cancers
Basic education, experience and skills required for consideration:
- PhD and/or MD/PhD.
- Evidence of first author peer-reviewed publications.
- Prior molecular, cancer biology and/or translational research experience and evidence of project development.
- Relevant experience in cancer genetics and epigenetics.
- Prior hands-on experience in developing cell-free DNA and RNA-based, liquid biopsy assays in cancers.
- Preference will be given to individuals who had previous experience with microarray and next generation sequencing-based platforms (MiSeq, HiSeq, NovaSeq, RRBS, ChIP-Seq, MeDip etc.).
- Strong background in biochemistry and/or molecular biology, as well as experience in identification and development of therapeutic targets in cancer (CRISPR/Cas-9, high-throughput target screens etc.).
- Desire to grow and develop skills in order to become an independent Investigator.
- Possess excellent communication and writing skills.
- Enthusiastic and highly motivated.
- Able to think creatively and independently.
- Possess good organizational skills.
- Able to work independently and in a team environment.
- Curriculum Vitae and coordinates of three scientific mentors.
- A cover letter highlighting your research interests, a brief statement explaining how your past research ties in with the goals of our laboratory, and future career plans.
City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.