Postdoctoral Scholar in Translational Signal Transduction Research
- H. Lee Moffitt Cancer Center
- Location: Tampa, FL
- Job Number: 7068355 (Ref #: hlj_26688)
- Posting Date: Jul 28, 2020
- Application Deadline: Open Until Filled
The H. Lee Moffitt Cancer Center and Research Institute has an opening for a postdoctoral scholar in translational signal transduction research. The Haura lab pursues an interdisciplinary approach spanning proteomics, chemical biology, translational medicine, molecular biology, biochemistry, and bioinformatics to characterize systems level views of cancer signaling networks. Particular emphasis is given to integrating functional proteomics technologies, e.g. chemical and phosphoproteomics, to dissect the underlying mechanism of drug action and cancer biology. See http://labpages.moffitt.org/haurae/Home.html
We are looking for a scientist with a cross-disciplinary skill set who is interested in working on projects focusing on system level understanding of RAS pathway targeting agents using mass spectrometry based proteomics. The project will consist of delineating pathways relevant for RAS pathway inhibitor sensitivity, determining adaptive signaling mechanisms using mass spectrometry that allow lung cancer cells to survive RAS pathway inhibitors (Kim, Molecular Cancer Research, 2016), assessing pathways activated in human lung cancers via phosphoproteomics with KRAS mutations, and determining if receptor tyrosine kinase protein complex annotation using proximity ligation assay (PLA) technology is associated with sensitivity to RAS pathway inhibitors (Smith, Science Signaling, 2015; Smith, Clinical Cancer Research, 2017).
The successful candidate must hold a PhD in cancer biology (or related discipline) and have extensive experience with cell signaling. A firm understanding of cancer signaling mechanisms will be highly beneficial. Candidates with experience in delineating signaling mechanisms in cells will be given priority. The position requires the ability to operate in an independent manner with limited supervision and to lead collaborative efforts across multiple disciplines within Moffitt and external industry collaborators. Strong written and verbal communication skills will be required. Opportunities for travel to relevant conferences, grant writing and mentoring are available.
Interested candidates should send CV, cover letter describing research interests and 2-3 references to Eric.Haura@moffitt.org.
Mission To create a Moffitt culture of diversity and inclusion as we strive to contribute to the prevention and cure of cancer. Vision Moffitt Cancer Center is recognized as the model wherein the diversity of our employees and communities is valued and supported as essential components to contributing to the prevention and cure of cancer. The cancer center is an equal opportunity employer. It is the policy of the cancer center to prohibit unlawful discrimination and harassment of any type and to afford equal employment opportunities to workforce members and applicants, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, national origin, age, marital status, disability, genetic information, veteran’s status or any other characteristic protected by federal, state or local law.