- City of Hope
- Location: Duarte, CA
- Job Number: 7073682 (Ref #: 10007290rxv_113_1)
- Posting Date: Jan 4, 2021
- Application Deadline: Open Until Filled
Job DescriptionPost-doctoral Fellow position is available immediately in the laboratory of Dr. Christiane Querfeld, M.D., Ph.D. at Beckman Research Institute of City of Hope.
About City of Hope
City of Hope, an innovative biomedical research, treatment and educational institution with over 6,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.
Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s leading cancer centers that develops and institutes standards of care for cancer treatment.
About the Querfeld Laboratory
Christiane Querfeld, M.D., Ph.D., director of the Cutaneous Lymphoma Program, seeks better treatment options for cutaneous T cell lymphoma (CTCL), a rare form of lymphoma that first appears on the skin but can also spread to lymph nodes and internal organs. City of Hope is one of the few institutions in the country that offers clinical trials to treat cutaneous lymphomas. Dr. Querfeld leads a multidisciplinary team of experts, including medical and radiation oncologists, pioneering treatments for CTCL and its subtypes.
Dr. Querfeld’s laboratory investigations are focused on the microenvironment in CTCL funded by NIH-NCI R01 and LLS scholar grants. She has demonstrated that cancer growth is fostered by the surrounding nonmalignant cells. These observations have led to the initiation of several targeted and immunologic therapies to restore the immune system and hereby killing the cancerous cells. Examples include a microRNA (miR155) antagomir that inhibits proliferation, an anti-CD47 construct enhancing macrophage killing and a randomized investigator initiated trial comparing the checkpoint inhibitor anti-PD-L1 with/without the immunomodulatory drug lenalidomide. Her fundamental laboratory research activities involve dissecting key signaling pathways to advance therapeutic immunologic strategies including mechanisms of resistance.
Key Responsibilities include:
- The ideal candidate should fit well with our research team focusing on the tumor microenvironment in cutaneous T cell lymphoma.
- Our research aims to identify the underlying mechanisms that promotes CTCL growth; specifically, the impact of immune cells such as macrophages and Tregs and to define novel targets.
- Expertise in handling of high-dimensional analysis of primary tissues, including multi parameter flow cytometry, immunohistochemistry, multiplex imaging and/or gene expression profiling, microRNA analysis, exosomes isolation and analysis (EG) for microRNA proteins cancer detection therapy is highly preferred.
- Participate in the preparation of research grants, manuscripts and presentations.
- Ensures that all laboratory activities are carried out in compliance with each procedure(s) by utilizing safety procedures and guidelines in handling, storage and disposal of bio-hazardous, infectious and toxic material.
- The candidate must follow established City of Hope and department policies, procedures, objectives, performance improvement, attendance, safety, environmental, and infection control guidelines, including adherence to the workplace Code of Conduct and Compliance Plan. Practices a high level of integrity and honesty in maintaining confidentiality.
- Performs other related duties as assigned or requested.
Minimum Education and Skills Required for Consideration
1 . A Ph.D. degree in life or biomedical sciences, or a related discipline is required.
2. Ability to effectively work and collaborate in a translational research environment in order to successfully meet deadlines and perform and prioritize simultaneous tasks. Requires use of discretion and judgment when handling confidential information.
3. Ability to design and execute experiments, critically interpret experimental results, and present data in a cogent and meaningful manner.
4. Candidate be industrious, has sound technical skills and capable drafting grant proposals, research protocols and manuscripts.
5. Under minimal direction of the Principal Investigator, works and is responsible for the development and execution of major research project and performs state-of-the-art, complex research projects in collaboration with the other researchers, making significant, original contributions to research methods; including authorship or co-authorship of published findings.
6. Ensures that all laboratory activities are carried out in compliance with each procedure(s) by utilizing safety procedures and guidelines in handling, storage and disposal of bio-hazardous, infectious and toxic material.
City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.