- The University of Texas M. D. Anderson Cancer Center
- Location: Houston, TX
- Job Number: 7073763
- Posting Date: Jan 6, 2021
- Application Deadline: Mar 8, 2021
Job DescriptionPostdoctoral position in basic and translational immune checkpoint biology and immunotherapy available in the lab of Dr. Michael A. Curran at the University of Texas MD Anderson Cancer Center. Dr. Curran was the first to study and report the combination of CTLA-4 and PD-1 blockade which remains the most effective clinical immunotherapy. The Curran lab studies mechanisms of immune resistance in “cold” cancers (prostate, pancreatic, glioblastoma), in particular focused on tumor hypoxia and oxygen metabolism, as well as on novel approaches to modulation of the tumor myeloid stroma. Research in the lab spans basic T cell co-stimulatory biology, tumor microenvironment studies in murine models, and ongoing clinical trials and associated correlatives. The lab offers unique resources for research in mice and in man, as we have developed our own novel immune checkpoint antibodies and uniquely potent agonists of the Stimulator of Interferon Genes (STING) innate immune sensor. Prior fellows hold tenured academic professorships, scientist positions in industry, and senior positions in patient-focused immune monitoring centers.
Successful candidates will lead a project to integrate modulation of cold tumor metabolism and T cell / myeloid stroma to foster immune rejection of “cold” cancers. Specific interest in immunobiology of glioblastoma and its immune microenvironment is a plus. Candidates must have a recent Ph.D. degree in a related field along with lead-author publications, excellent communication skills, and the ability to work independently within a research team. Candidates who pursue an independent career path are highly preferred. Expertise in cancer immunology, murine tumor modeling, and/or tumor/immune metabolism is also desirable. We will provide a competitive salary at or exceeding the NIH postdoctoral stipend level, excellent benefits, and one-on-one mentoring and coaching for a successful research career.
Diversity and inclusion at MD Anderson are not just important; they are essential. We take an expansive view of diversity, considering differences in race, ethnicity, sexual orientation, gender and religious beliefs, as well as communication styles, thought, skill and ambition. We constantly examine our culture to create an inclusive working environment that effectively attracts, retains, develops and utilizes the skills and talents of all employees. Our Diversity Council develops strategies to attract and retain superior talent and enhance workforce diversity and inclusion. We also offer multiple diversity training programs to our employees.