Postdoctoral Fellow - CAR T Cell Therapy approach to Type 1 Diabetes
- City of Hope
- Location: Duarte, CA
- Job Number: 7073911 (Ref #: 10009201)
- Posting Date: Jan 9, 2021
- Application Deadline: Open Until Filled
Job DescriptionAbout City of Hope
City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.
Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s leading cancer centers that develops and institutes standards of care for cancer treatment.
The Beckman Research Institute at City of Hope is seeking a highly motivated Postdoctoral Fellow to participate in a novel project developing an immunotherapy for type 1 diabetes, a disease in which insulin-secreting pancreatic β cells are targeted and destroyed by a patient’s autoreactive T cells. One approach for treatment of patients with type 1 diabetes is reducing or eliminating these autoreactive effector memory T cells (TEM) while sparing T cell populations required for normal adaptive immunity. The goal of this project is to design a chimeric antigen receptor (CAR) to selectively target an antigen overexpressed by these TEM cells and evaluate its potential in preclinical studies.
Key Responsibilities include:
The research fellow will utilize multiple molecular, cellular and imaging techniques to design a CAR targeting an already identified target and express this CAR in human T cells with the eventual goal of adoptive transfer to patients with type 1 diabetes.
The ideal candidate will have experience in CAR T cell therapy or other immunotherapies, and/or cellular biology related to type 1 diabetes.
Core competencies include molecular design and protein expression in mammalian cells, as well as those related to acquisition of high-dimensional expression analyses of primary tissues.
This person will be working as part of a large group of researchers focused on developing T cell therapies in a translational research environment.
Basic education, experience and skills required for consideration:
Doctoral-level degree (PhD, MD, or similar) in the fields of immunology, immunotherapy, and/or type 1 diabetes.
Experience in molecular design and protein expression in mammalian cells, together with experience in high-dimensional gene expression analyses of primary tissues.
Demonstrated ability to prepare manuscripts and/or grant proposals, along with a publication record in peer-reviewed scientific journals.
For further information on projects presently underway, please see the Dr. Christine Brown laboratory webpage at: https://www.cityofhope.org/research/beckman-research-institute/research-departments-and-divisions/immuno-oncology/christine-brown-lab
City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.
City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.