Postdoctoral Research Fellow
- The University of Texas Health Science Center at Houston
- Location: Houston, TX
- Job Number: 7075621
- Posting Date: Mar 3, 2021
- Application Deadline: May 2, 2021
Job DescriptionThe NIH-funded postdoctoral position is available in the laboratory of Dr. Anna Konovalova at the Department of Microbiology and Molecular Genetics.
The laboratory is focused on how Gram-negative bacteria build and maintain the integrity of their cell envelope, the hallmark of which is the outer membrane. The outer membrane is essential and serves a major factor of intrinsic antibiotic resistance. We aim to provide a deep functional understanding of the OM assembly and homeostasis pathways and their interconnectivity as the first step in the scientific roadmap to antibiotic discovery. We combine classic genetics with innovative screens and state-of-the-art biochemistry. Our research interest lies in two major areas: i) Biogenesis of surface-exposed lipoproteins (SLPs). Our goal is to define the mechanism of lipoprotein targeting and export to the bacterial cell surface to enable the development of predictive computational models for lipoprotein localization and genomic identification of SLPs. ii) Envelope stress responses. We study envelope stress responses both on the molecular level to determine mechanistic aspects of the signal transduction and on the system level, to determine the global regulatory networks that ensure the fidelity of the envelope assembly under different growth conditions, including antibiotic challenges.
We seek applicants who are motivated, rigorous and creative. Applicants should have or will shortly earn a Ph.D. in microbiology, molecular biology or a related field. Extensive experience in conducting molecular biology, genetics and/or biochemistry experiments is required. Additionally, applicants should have strong written and oral communication skills and work well with others.
To apply, please email 1) CV, 2) a brief description of your research background and interests, and 3) the contact information of three referees.