Postdoctoral Fellow - Leukemia (Bhalla)
- The University of Texas M. D. Anderson Cancer Center
- Location: Houston, TX
- Job Number: 7075978
- Posting Date: Mar 12, 2021
- Application Deadline: Open Until Filled
Job DescriptionThe focus of the basic and translational research in this laboratory includes the biology and developmental therapeutics related to epigenetic mechanisms involving histone deacetylases, methyltransferases and demethylases, BET proteins, as well as the chaperone biology of heat shock proteins and their cancer-relevant client proteins regulating cell growth, differentiation, and survival of the human leukemia stem/progenitor cells.
1.) Develop skills in experimental design and conduct of biologic and molecular studies to characterize genomic alterations, epigenomic, transcriptional, and protein expression studies (ATAC-Seq, ChIP-Seq, RNA-Seq, Confocal Microscopy, Flow Cytometry, Mass Cytometry, and Western analysis) in bulk cell populations as well as at a single-cell level.
2.) Cloning and transfer of genes into cancer cells.
3.) CRISPR-Cas9 techniques for gene-editing.
4.) Mouse xenograft models to determine the biology of leukemia and lymphoma as well as to evaluate the therapeutic efficacy of novel targeted agents.
The qualified candidate must possess a Ph.D. in Biology, Biological Sciences, Life Sciences, or related field; a keen interest and experience in cancer research; excellent English skills (both written and verbal); and current U.S. work authorization. The candidate should preferably have completed a 3-year Post-doctoral fellowship in an area relevant to the focus of research noted above. The qualified candidate must have the ability to troubleshoot in the design and conduct of the laboratory studies. Experience in molecular studies involving gene transfection, analysis of gene expression through qPCR, microarrays, immunoblots, and flow cytometry, as well as experience in chromatin immunoprecipitation studies, evaluation of protein biochemistry with 2D gels and the yeast two-hybrid system, and tissue culture techniques is preferred. Experience in the ability to utilize CRISPR technology for gene editing and to utilize confocal microscopy for molecular imaging is preferred. Experience in xenograft and genetically-engineered animal models of cancer and/or leukemia, and confocal microscopy is also preferred.
This position reports to Kapil Bhalla, M.D.
Qualified applicants should send CV's to: KBhalla@mdanderson.org
Additional Application Information:
Monday - Friday, 8:00 - 6:00; Weekends when needed.
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