- University of Pennsylvania
- Location: Philadelphia, PA
- Job Number: 7076299
- Posting Date: Mar 24, 2021
- Application Deadline: Open Until Filled
Job DescriptionThe Mason lab at the University of Pennsylvania’s School of Veterinary Medicine is seeking a full time post-doctoral researcher for an NIH/NCI sponsored project focused on developing allogeneic CAR T cell therapies for the treatment of cancer. The overarching aim of the project is to understand the barriers to effective engraftment and survival of allogeneic CAR-T and devise strategies to enable the safe transfer and persistence of allo-CART. The successful candidate will utilize CRISPR/Cas9 editing and gene transfer technologies to generate edited CAR-T cells. In vitro and in vivo studies will be performed to assess the effectiveness of editing on persistence and function. Client owned dogs with spontaneous cancer will be recruited to a clinical trial to evaluate safety and efficacy of engineered allogeneic canine CART cells approach in the veterinary oncology clinic. The successful candidate will be a motivated and talented immunologist with a keen interest in translational research and the use of adoptive T cell therapies. They will join an expanding team that works in collaboration with colleagues and collaborators at the University of Pennsylvania’s School of Medicine.
Qualifications: A doctoral degree (Ph.D. or MD/Ph.D or DVM/Ph.D. or equivalent) in immunology or cellular and molecular biology is required. Relevant cellular and molecular biology skills including cell culture, genetic engineering, viral transduction, flow cytometry, and immune function analysis including cellular proliferation and cytotoxicity assays, ELISA, and ELISpot assays are required. Prior experience with cell-based therapies is desirable. The successful candidate must be fluent in English and have good scientific writing skills. Individuals with US citizenship or permanent residence are preferred.
The University of Pennsylvania provides a stimulating and academically rich environment and is a world leader in cancer immunotherapy. The close association of the veterinary and medical schools on campus provides ample opportunity for collaborative research between the two schools.
The University of Pennsylvania is an equal opportunity employer that does not discriminate based on race, color, religion, sex or gender identity, age, disability, sexual orientation or genetics. A competitive salary and benefit package are offered that are commensurate with NIH post doctoral salaries.