Research Fellow in Computational Biophysics
- University of Leeds
- Location: Leeds, United Kingdom
- Job Number: 7077975 (Ref #: MHLCM1250)
- Posting Date: May 7, 2021
Are you an ambitious researcher looking for your next challenge? Do you have a background in computational biophysics or biomolecular simulations? Do you want to further your career in one of the UK’s leading research intensive Universities?
This new and exciting position is funded by the British Heart Foundation and will enable us to extend our studies on the newly discovered Piezo1 mechanosensitive channel. Piezo1 channel is a critical mechanical sensor in endothelial cells, red blood cells and other cell types such as cardiac fibroblasts. Mutations on Piezo1 have been shown to result in a number of cardiovascular diseases. Building a detailed molecular and dynamic understanding of Piezo1, which will complement the available structural and functional data, will fill an important gap in our understanding of the function of this biologically important channel.
You will use modelling and simulation tools to perform molecular dynamics simulations of Piezo1 channel in complex model membranes both at the coarse-grained and atomistic resolution. These simulations will enable us to answer key questions about the activation and ion permeation mechanism of Piezo1. You will work in the group of Dr Antreas Kalli at the Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM), and the work will involve close and interactive collaboration with the groups of Prof. David Beech and Dr. Jian Shi (LICAMM) who will evaluate the models derived from the computational work.
To explore the post further or for any queries you may have, please contact:
Dr Antreas Kalli, University Academic Fellow, University of Leeds
The University of Leeds is committed to providing equal opportunities for all and offers a range of family friendly policies. The University is a charter member of Athena SWAN and holds the Bronze award. The School of Medicine holds the Gold award. We are committed to being an inclusive medical school that values all staff, and we are happy to consider job share applications and requests for flexible working arrangements from our employees.
|Location:||Leeds - Main Campus|
|Faculty/Service:||Faculty of Medicine & Health|
|School/Institute:||Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM)|
|Section:||Discovery and Translational Science Department (DTSD)|
|Salary:||£33,797 to £40,322 p.a.|
|Working Time:||1.0 full time equivalent|
|Post Type:||Full Time|
|Contract Type:||Fixed Term (2 years (external funding))|
|Release Date:||Thursday 06 May 2021|
|Closing Date:||Thursday 03 June 2021|
The University community is made up of a wide range of people with diverse backgrounds and circumstances, which we value and regard as a great asset. As part of our continued commitment to equality and inclusion, we strive to create an environment where everyone can reach their full potential and have a real opportunity to participate in and contribute to our activities.