- Massachusetts Institute of Technology
- Location: Cambridge, MA
- Job Number: 7081701
- Posting Date: Jul 29, 2021
- Application Deadline: Open Until Filled
Job DescriptionPOSTDOCTORAL ASSOCIATE, Biology-Sauer and Davis Labs, to probe the structure and function of macromolecular machines such as energy dependent proteases and ribosomes. Representative work from the Sauer and Davis labs includes: CryoDRGN: reconstruction of heterogeneous cryo-EM structures using neural networks; Modular Assembly of the Bacterial Large Ribosomal Subunit; and Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates. Will work to determine complex structures using single-particle cryoEM and to integrate these structures with decades of biochemical studies to understand how these machines assemble and function.
This jointly advised position is fully funded and affords an opportunity to employ a combination of biochemical and computational approaches and to be simultaneously mentored by both an established and new investigator. Additionally, there will be an opportunity to develop a completely independent project on a ~15-20% time basis.
REQUIRED: Ph.D. in biology or closely related field; experience purifying and imaging protein complexes, generating 3D reconstructions with traditional tools such as Relion, and an interest in helping to further develop and employ new methodssuch as CryoDRGN to analyze heterogeneous structural ensembles. Job #19586
In addition to applying through the MIT website, interested applicants are asked to email their information to firstname.lastname@example.org to describe their interest in the position, to provide a curriculum vitae, and to supply contact information for three references.
This is a temporary, one-year position.