Postdoctoral Fellow Positions in Houston, Texas (Human neurodevelopment disorder, Epigenomics and 4D Nucleome)
- University of Texas Health Science Center at Houston
- Location: Houston, TX
- Job Number: 7082767
- Posting Date: Aug 11, 2021
- Application Deadline: Open Until Filled
Job DescriptionOne fully supported postdoc position is immediately available in the lab of Dr. Wenbo Li in the Department of Biochemistry and Molecular Biology, McGovern Medical School, University of Texas Health Science Center at Houston, Texas, USA.
Research Summary: Our lab focuses on RNA-mediated gene regulation and 3D chromatin organization. We are a member of the NIH 4D nucleome (4DN) program (https://commonfund.nih.gov/4dnucleome). Our overarching goal to decipher the functions of noncoding DNA and RNA elements in the human genome in gene transcriptional control, which can ultimately help to improve human disease intervention. Our lab utilizes biochemical methods and various omics approaches (e.g., ChIP-seq, PRO-seq, Hi-C, CLIP-seq etc.), as well as (epi)genome editing tools (CRISPR/Cas9/dCas9/Cas13). Candidates are encouraged to read the recent publication of Dr. Li’s lab (Nature reviews. Genetics. 2016; Nature Communications. 2019; RNA Biology. 2020; Oh et al., 2021, Nature; Xiong et al., 2021, Cell Research; Lee et al., Mol Cell, 2021; Wang et al., BioRxiv, 2021).
A complete list of Dr. Li’s publication can be found in PubMed:
https://www.ncbi.nlm.nih.gov/myncbi/1Jip8J4DFUsQe/bibliography/public/; or Google Scholar: https://scholar.google.com/citations?hl=en&user=cBKgsuAAAAAJ
About the current position: We are looking for motivated postdocs with an enthusiasm to uncover fundamental biology mechanisms of gene transcriptional control in normal human neurodevelopment and in disorders (particularly the Down Syndrome). The candidate will focus on using novel epigenomic tools (such as Hi-C or advanced imaging) to dissect a largely unappreciated side of human neurodevelopment – the regulation and deregulation of the 3D genome. Our lab provides ample opportunities for collaboration within the Texas Medical Center, the largest Medical Center in the world. As a member of the NIH 4D nucleome (4DN) program, postdocs in our lab have opportunities to attend 4DN consortium group meetings, will be exposed to world frontiers of 3D genome research. These opportunities will be very beneficial for the candidates’ research career. Competitive salary and benefits will be provided. In terms of location, Houston is a rapidly growing city with a vibrant culture, offers an ideal environment for life and career.
About you: The candidates are expected to be: 1) highly motivated; 2) have a recent PhD, or MD/PhD degree, with first-author publications; 3) have extensive experiences in molecular biology, biochemistry, genetics or cell biology; 4) excellent communication skills and a solid knowledge of molecular biology and transcriptional regulation are required, preferably in one of the areas of epigenetics, developmental biology or molecular neuroscience.
Some required methods by this position will include: RT-qPCR, RNA-Seq, ChIP-Seq, ATAC-Seq, Hi-C, human iPSC and ESC culture, in vitro differentiation of ESCs/iPSCs to neural lineages, 3D cortical organoid. Therefore, prior experiences in working with human ESC/iPSC or their differentiation are highly preferred.
To apply: Contact Dr. Li at Wenbo.firstname.lastname@example.org, with an email title of “Postdoc _your name_degree granting institution and year”. For example: “Postdoc_ Jason Smith_UTexas_2020”. Please be prepared to provide: 1) your detailed cv, 2) a brief description of your short term and long-term goals, scientific background and interests (in 2 pages); and 3) the contact information for two to three referees who can provide a recommendation letter. You are welcome to inquire via email if you have questions.