- Do you have a PhD in a relevant discipline area, such as microbiology or cellular and molecular biology or similar?
- Join a strong multidisciplinary team to apply an ex vivo human intestinal organoid system to improve our understanding of human health
- Join CSIRO – Australia’s leading scientific research organisation!
CSIRO Early Research Career (CERC) Postdoctoral Fellowships provide opportunities to scientists and engineers who have completed their doctorate and have less than three years of relevant postdoctoral work experience. These fellowships aim to develop the next generation of future leaders of the innovation system.
The position will be part of the Microbiomes for One Systems Health - Future Science Platform (FSP). CSIRO FSPs address new scientific challenges for Australia.
The Microbiome FSP is developing new understanding of microbiome connectivity across the environment to human continuum and how system perturbations impact on microbiome functionality, diversity and systems health. A key objective is to capture greater benefit from microbiome interactions through more informative and predictive frameworks for functionality and by targeted interventions. Capacity to directly manipulate microbiomes across hosts and environments will provide new opportunities for bio-based solutions to be developed and applied to improve host and environmental health and for increased benefit to plants, animals and humans.
The portfolio of research within the Microbiome FSP is focussed around new science that address; systems connectivity, predictive frameworks and deliberate Interventions through the application of multi-omic tools to analyse point and system level change and associated measures of functionality both within and across interconnected biomes. This includes integration and analysis of multi-layered data and use of empirical and/or statistical modelling. The science portfolio of the FSP spans multiple CSIRO Business Units that address key focal areas that include; i) Environment, Soil & Plant Health, ii) Food Chain & Production ii) Diet, Gut and Health and iv) Optimized Industry & Urban Processes.
This is an exciting opportunity for a Postdoctoral Fellow to join a project that will establish genetically diverse normal and disease matched intestinal organoids, co-cultured with host microbial community and microenvironment, as a platform to understand microbe-microbe interactions and host-microbe interactions within a relevant physiological environment. The Postdoctoral fellow will join a strong multidisciplinary team within the Molecular Diagnostics Solutions team to apply an ex vivo human intestinal organoid system to improve our understanding of human health. Derived from patient biopsy tissue, these 3D organoid cultures retain both the cellular architecture and cellular diversity of the large intestine, making them physiologically representative of the tissue from which they are derived. This will ultimately contribute to our understanding of how gut microbial communities can be influenced to improve human health. The Postdoctoral Fellow will be exposed to a range of new and cutting-edge approaches with ample opportunity for further training and development, especially in metagenomics, bioinformatics and biostatistics.