Postdoctoral Fellow on immunometabolism in neutrophil functions
- The University of Texas M. D. Anderson Cancer Center
- Location: Houston, TX
- Job Number: 7086389
- Posting Date: Sep 30, 2021
Job DescriptionProgram Description:
A Postdoctoral position for NIH-funded project is available in the laboratory of Dr. Jyotika Sharma at MD Anderson Cancer Center. The major research focus of Sharma laboratory is to understand neutrophil functions in regulation of inflammation. Using murine transgenic models and clinical samples for infectious and sterile immune disorders such as pneumonic sepsis, CGD, COPD, metabolic diseases and breast cancer our laboratory is investigating the mechanisms of neutrophil extracellular trap (NET) formation, granulopoiesis and neutrophil efferocytosis. With our recent mechanistic discoveries, a major thrust in the laboratory is therapeutic modulation of neutrophil-mediated responses in disease specific manner, a yet unmet clinical need. Using FDA approved drugs, novel anti-inflammatory biofactors isolated from helminth parasites; and small-molecule inhibitors we are engaged in identifying strategies to control pathological neutrophil responses without affecting the antimicrobial function of neutrophils.
This project aims to generate mechanistic understanding of the metabolic reprogramming that affects formation of neutrophil extracellular traps (NETs) and inflammatory immune responses in human disease conditions; and determining how neutrophil metabolic landscape affects NET formation mediated by C-Type lectin receptor Mincle and its interaction with a newly discovered endogenous ligand.
Successful candidate will benefit from a dynamic and collaborative research environment in the laboratory, mentoring and networking opportunities, interaction with clinical investigators, access to state of-the-art research facilities and clinical samples.
Completed Ph.D. or MD/Ph.D. in immunology or any field relevant to the biology of human disease. The applicant will have research competence evident by relevant first author publications in respected field journals. Strong communication skills in English are essential.The position requires hands-on experience with primary cell culture, multicolour flow-cytometry, microscopy, immunostaining and mouse models of infection and disease.
Prior experience with metabolic assays and animal models of immuno-metabolic disorders is desirable but not required.
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html