Post-doctoral Fellow, Single-Cell Chemical Proteomics
- Bristol Myers Squibb
- Location: Cambridge, MA
- Job Number: 7089927 (Ref #: R1542481)
- Posting Date: Dec 1, 2021
- Application Deadline: Open Until Filled
Job DescriptionCambridge - MA - US
At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
The Small Molecule Drug Discovery (SMDD) Discovery & Translational Proteomics team is seeking a talented and enthusiastic Postdoctoral Fellow who will advance a state-of-the proteomics platform and apply it to the study of small molecule protein degraders. This is a unique opportunity to impact the undruggable target space in drug discovery using state-of-the-art technology. The successful candidate will work at the intersection of chemical biology, medicinal chemistry, immunology, analytical chemistry/bioinformatics, and will possess an enthusiasm for drug discovery, strong scientific curiosity, and aptitude for learning. The postdoc will be supported by a cross-functional team of mentors and collaborators who are leaders in their respective fields. The postdoc will lead communication of the team’s findings in high-impact publications. Previous experience with mass spectrometry is not required.
Generate comprehensive global protein degradation profiles of a small library of protein degraders in primary single cell subtypes.
Develop bioinformatic tools to analyze single-cell proteomes in collaboration with colleagues in Information and Predictive Sciences (IPS) by applying deep learning/machine learning approaches.
Analyze structure-activity relationships and generate mechanistic understanding of degradation including on- and off-target effects and temporal dynamics.
Deepen biological understanding of novel molecular interactions by performing cell-based functional assays.
Optimize the acquisition of single-cell proteomes using state-of-the-art LC-MS systems including hands-on instrument operation.
Establish an efficient, automated, one-pot sample processing workflow in collaboration with proteomics team members.
Isolate single cells using both fluorescence-activated cell sorting (FACS) and image-based cell selection using a cellenONE dispenser.
Perform proteomics data analysis using commercially available or free software.
Communicate findings to the team, create and present research updates, and lead the generation of publications
Maintain electronic laboratory notebooks
Comply with laboratory safety practices
Qualifications & Experience
Ph.D. in biological or chemical science (chemical biology, immunology, analytical chemistry, cell/molecular biology, or related discipline).
Self-starter who can drive projects while collaborating effectively in a cross-functional team.
Experience working at the bench at the interface of multiple subjects and communicating results to cross-functional teams.
Passion for enabling drug discovery, technology development, and working at the intersection of biology, medicinal chemistry, and pathophysiology.
Demonstrated ability to analyze and present complex data sets.
Track record of high-impact publications in peer-reviewed journals.
Strong written and verbal communication skills.
Chemical biology or pharmacology experience determining small molecule mechanism-of-action and/or compound-target interactions.
Expertise in isolation and characterization of primary immune cells.
Experience with single-cell techniques such as CyTOF or single cell sequencing.
Proteomics mass spectrometry experience including large scale or automated sample preparation, instrument operation, or high-density proteomics data analysis.
Expertise in machine learning, statistics, and the fundamental programming tools of bioinformatics and computational biology (e.g. R or Python)
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.