Post-doctoral Fellow, Cardiovascular and Fibrotic Diseases
- Bristol Myers Squibb
- Location: Cambridge, MA
- Job Number: 7089938 (Ref #: R1542488)
- Posting Date: Dec 1, 2021
- Application Deadline: Open Until Filled
Job DescriptionAt Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
We seek a talented and collaborative scientist to use human genetics to gain insights in disease pathobiology and enable the development of novel drugs for Heart Failure. The successful candidate will develop and apply computational pipelines to elucidate causal mechanisms through integrative analyses (e.g. Mendelian randomization) of proteomics and clinical data from public and proprietary sources to identify causal mechanisms that drive Heart Failure. The position offers an exciting opportunity to gain industry experience and interact with the broader scientific community. The candidate will work closely with collaborators at the University of Pennsylvania and other academic institutions, who are scientific leaders in the field of HF translational research. The candidate will have the opportunity to publish their work, and to present at external meetings and conferences.
Mapping protein quantitative trait loci (pQTL) across multiple contexts and data sources, including; a cohort of Heart Failure patients and UK Biobank.
Test and apply statistical genetics tools to identify context-specific pQTL related to Heart Failure
Perform Mendelian randomization across pQTL and multiple Cardiovascular disease endpoints
Apply polygenic risk scores to segment Heart Failure patient populations based on disease mechanism
Communicate findings in multiple settings (including 1:1, seminars, group, and project meetings)
Qualifications & Experience
PhD in genetics/genomics, computational biology/bioinformatics, statistics, computer science/math/engineering or related field
Expertise in statistical genetics, especially experience with methods such as; GWAS, eQTL/pQTL, co-localization, fine-mapping, Mendelian randomization, Polygenic risk scores or PheWAS
Experience with relevant programming/scripting tools (e.g. R, MATLAB, Python, C/C++).
Knowledge and/or interests in Cardiovascular disease biology a bonus.
Excellent written and oral communication skills.
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.