Postdoctoral fellowship on epigenetic regulation and the DNA Damage response in normal and malignant hematopoiesis
- The University of Texas M. D. Anderson Cancer Center
- Location: Houston, TX
- Job Number: 7090737
- Posting Date: Dec 16, 2021
- Application Deadline: Open Until Filled
Job DescriptionA postdoctoral fellow position in epigenetic regulation and the DNA Damage response (DDR) in normal and malignant hematopoiesis is immediately available in the lab of Dr. Margarida Santos. The research will focus on the intersection of epigenetics and the DDR in acute myeloid leukemia as well as diffuse large B cell lymphoma. The long term goal is to understand the mechanisms through which Epigenetic regulation and its interplay with the DDR occurs during normal differentiation and how these processes become disrupted in human diseases and use this information to develop specific and potent therapeutic strategies.
Training and research activities will include work with genetic mouse models of acute myeloid leukemia and diffuse large B cell lymphoma, as well as human cell lines and patient derived samples of these two models of cancer. In addition, techniques as RNA sequencing and chromatin immunoprecipitation sequencing will also be performed among other molecular biology techniques. Fluorescent microscopy and confocal microscopy are also components of the research program.Our lab is a part of the Center for Cancer Epigenetics at MD Anderson Cancer Center, and we continue to advance our efforts to define how Epigenetic Regulation and the DNA damage response contribute to normal hematopoiesis as well as drive malignant transformation in Blood Cancers.
Candidate must be a recent Ph.D. or MD/Ph.D. graduate in biochemistry, genetics, immunology, cancer biology, or similar field. An excellent publication record (only candidates with one or more first-authored publications in a high impact journal(s) will be considered), along with experience in generating/characterizing mouse models, flow cytometry, retroviral transduction, mammalian cell culture and next generation sequencing is required. Previous experience in scientific writing or grant preparation in English is required.
Please apply at the link below.
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