Postdoctoral Fellow - Genetics and Epigenetics of Gastrointestinal Cancers
- City of Hope
- Location: Monrovia, CA
- Job Number: 7092367 (Ref #: 10011490)
- Posting Date: Jan 17, 2022
- Application Deadline: Open Until Filled
About City of Hope
City of Hope, an innovative biomedical research, treatment and educational institution with over 6000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.
Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment.
We currently have multiple Postdoctoral Fellowship positions within the multidisciplinary research team headed by Dr. Ajay Goel, Professor and Chair, Department of Molecular Diagnostics and Experimental Therapeutics and Associate Director of Basic Sciences, City of Hope Comprehensive Cancer. Our multidisciplinary research group comprises of basic biologists, gastroenterologists, surgeons, oncologists and bioinformaticians, undertaking a number of collaborative projects involving large international consortia.
Our research is focused on translational research as it relates to genomic and epigenomic characterization of various gastrointestinal cancers (GI) including colorectal, pancreatic and gastric cancers, and some of the key research topics include: 1) Development of circulating DNA/RNA-based liquid biopsy biomarkers for cancer diagnosis, prognosis and predictive response to various therapies. 2) Study the epigenetic basis of GI cancers (e.g. aberrant DNA methylation, histone modifications and non-coding RNAs. 3) The genetic basis of early-onset and familial/hereditary colorectal cancers. 4) The role of tumor microenvironment, stem cells, immune regulation and identification of novel targeted therapies. 5) The role of extracellular vesicles/exosomes as in cancer pathogenesis and their role as disease biomarkers. Our group performs cutting-edge research in GI oncology, is very productive and publishes in high-impact journals such as Gastroenterology, JNCI, Clinical Cancer Research, Nature Communications, Annals of Surgery etc.
Key Responsibilities include:
- Devise, plan, document and advance basic science and translational projects in the area of precision oncology of gastrointestinal cancers.
- Generate data for grant applications and prepare manuscripts for publication.
- Work in close collaboration with other team members and external collaborators, including presentation of progress internally or externally.
- Train and supervise technical staff.
Basic education, experience and skills required for consideration:
- Recent PhD, MD or MD/PhD, with a strong background and profound knowledge in the field of oncology, cancer biology, immunology or immunotherapy.
- Ability to work in a fast-paced research environment and manage multiple projects and collaborations.
- Previous experience in working with human specimens and development of novel, innovative cancer biomarkers.
- Evidence of scientific rigor and excellence as documented by high-impact peer-reviewed publications.
- Strong team player with excellent communication skills and fluency in English, both spoken and written.
- Commitment to the program for at least two-three years.
- An opportunity to have the unique possibility to drive research towards a novel cancer therapy at the interface of science and translation to the clinic and publish high-impact journals.
- To apply, please submit your current CV/resume with a cover letter highlighting your research accomplishments, a brief statement explaining how your past research ties in with the goals of our laboratory, and future career plans.
- For more information about the groundbreaking research taking place in the Ajay Goel, PhD lab, please visit www.cityofhope.org/mdet.
- To protect the health of patients and staff and to comply with new State of California mandates, City of Hope staff are required to show proof of full vaccination by September 30, 2021. Compliance is a condition of employment.
City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.
City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.