Highly motivated individuals with a PhD or MD/PhD in relevant area are encouraged to apply. This training position, under the direct supervision of a Cleveland Clinic Principal Investigator will provide practical training and experience in a research setting. This position is appointed through the Lerner Research Institute. The successful applicant will be able to demonstrate a commitment to research, a collaborative work ethic and strong communication skills, both written and verbal. This program is expected to be completed within 5 years.

The Charis Eng laboratory is seeking a highly motivated, self-driven postdoctoral research fellow for the Genomic Medicine Institute at Cleveland Clinic Lerner Research Institute. The successful candidate will have demonstrated proficiency in neurodevelopment and neuron-glial interaction research, mouse work and experiment design, and will apply those skills to elucidate the cellular and molecular mechanisms contributing to PTEN mutation-driven autism spectrum disorder observed in germline PTEN patients. The postdoctoral researcher will be directly responsible for conducting experiments and analyzing data under Dr. Eng’s mentorship and must be willing and able to work as part of a team, learn new techniques and mentor others. 

The Genomic Medicine Institute is an interdisciplinary institute and department committed to performing translational and clinical human genetics and genomics investigation. A major focus of the Eng Lab is to utilize multi-disciplinary approaches – classical genetics, genomics, metagenomics, computational/systems biology, immunology, computational biophysics, animal modeling, and molecular biology – to elucidate the molecular mechanisms that contribute to cancer predisposition and neurodevelopmental disorders (e.g., autism spectrum disorder), and other PTEN-related phenotypes in the context of germline PTEN disruption.

Principal Investigator: Charis Eng, MD PhD

Lerner Research Institute Department: Genomic Medicine Institute

Lab Research Topics:

Job Responsibilities:

• Independent project design with the goal of data generation, analysis, interpretation and manuscript preparation
• Provide clear, detailed and thorough progress reports
• Mouse husbandry, genotyping, tissue collection
• Data analysis, presentation, grant and manuscript preparation

Education:

• PhD or MD/PhD required
• MD with relevant laboratory experience may substitute for PhD

Languages:

• English Proficiency proof required for candidates arriving on J-1, J-2, or F1 + OPT visa status

Work Experience:

• Previous experience in a research or academic setting.  Graduate student experience meets this requirement.
• Scientific writing experience

Additional Preferred Qualities:

• PhD required
• Highly motivated and self-driven individual with exemplary work-ethic and ability to promote team-spirit/collegiality
• Strong background in development and function of glia and neurons
• Experience in mouse behavior and neurophysiology
• Proficient in Western blot, IF, ELISA, qRT-PCR, cryotome / microtome sectioning
• Good aseptic technique, and cell-culture experience

Personal Protective Equipment:

• PPE per institutional requirements; may vary by laboratory

Preferred Application Materials:

Applicants should include a CV, cover letter and contact information for three references to Dr. Charis Eng at [email protected].  

Keywords: Postdoc, Research, Lerner Research Institute, Genomic Medicine Institute, PTEN, Autism, Neuroscience, Neurodevelopment, Microglia, Synapses, Neuroinflammation

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