Job Description

SALARY
Commensurate with accumulated relevant research experience and NIH pay scale. We are seeking and enthusiastic and talented candidate with a Ph.D. in cancer biology, genetics, molecular biology, experimental therapeutics, bioinformatics or related filed. The candidate is expected to be highly motivated, possess excellent presentation and interpersonal skills.

DESCRIPTION OF DUTIES
Performs a variety of routine and specialized lab tests and experimental procedures.
Assists with research planning and conduct, to include data collection, initial interpretation, and troubleshooting as necessary.
Will have access to patient database, tissue specimen, cell culture, patient derived xenograft, next generation sequencing and genetic mouse model.
Assist with writing animal and human trial protocols, manuscripts and grants.

PREFERRED QUALIFICATIONS
PhD in cancer biology, genetics, bioinformatics or related field.
Research experience in human genetics, drug experiments & molecular biology.
Experience with genetically engineered mouse models, mouse breeding/care.
Demonstrated proficiency in data analysis in molecular and cancer biology.
Publications in high impact peer-reviewed journals.

ADDITIONAL SKILLS NEEDED
Excellent written and verbal communication and organizational skills .
Experience with next-generation sequencing data, RNAseq, single-cell sequencing and common analysis tools
Experience with R related to probability and statistics.

RESEARCH PROJECTS
Identify novel therapeutic targets that drive bladder cancer development and progression.
1. Xu, D et al. A preclinical Study to Repurpose Spironolactone for Enhancing Chemotherapy Response in Bladder Cancer. Molecular Cancer Therapeutics. 2022 May;21(5):786-798. doi: 10.1158/1535-7163.
Genetically engineered mouse models (GEMMs) of bladder cancer to investigate molecular mechanisms of bladder cancer variant histology, differentiation, progression, and metastasis using in vivo analyses of GEMMs and patient-derived organoid models.
1. Xu, D et al. Single-Cell Analyses of a Novel Mouse Urothelial Carcinoma Model Reveal a Role of Tumor-Associated Macrophages in Response ot Anti-PD-1 Therapy. Cancers (In Press).
2. Xu, D et al. Ex Vivo Organoid Model of Adenovirus-Cre 582 Mediated Gene Deletions in Mouse Urothelial Cells. J. Vis. Exp. 2022, e63855, doi: 10.3791/63855.)

APPLICANT INSTRUCTIONS
Interested candidates should submit a cover letter, resume or CV and contact information of three referees to:
Shannon Zelli at [email protected] or Dr. Qiang Li at [email protected]