RNA Accelerator Postdoctoral Research Fellow, Cancer Immunology Discovery
- Pfizer Inc.
- Location: Cambridge, MA
- Job Number: 7106098 (Ref #: 4860600)
- Posting Date: Jul 21, 2022
- Application Deadline: Open Until Filled
Job DescriptionROLE SUMMARY
The Cancer Immunology Discovery group at Pfizer is seeking an ambitious Post-Doctoral Research Scientist with strong research and communication skills to undertake a highly visible research project shared between the CID and BioMedicine Design groups. The successful candidate will aim to leverage mRNA lipid nanoparticle (mRNA-LNP) technology to enhance T cell activity against tumors. This work will depend heavily on the candidate’s ability to derive novel in vitro/in vivo experimental models and complete related experiments to give an early glimpse at the clinical potential of this approach.
We are seeking a self-starting, highly motivated, and technically proficient scientist with a PhD in Immunology or Cancer Biology to apply a variety of cutting-edge tools including molecular, cellular, and biochemical techniques alongside immunofluorescence imaging, high parameter flow cytometry, and bioinformatics in preclinical in vivo models to address key questions within the scope of the proposed work. (S)he will work in a fast-paced and highly collaborative research environment and will be expected to present their findings in high-impact journals and at internal and external scientific conferences.
PhD degree with experience in Immunology, Tumor biology, Oncology, or related discipline.
A high-level understanding of key concepts in cancer immunology
A strong desire to learn, it is not expected that the successful candidate will have experience with all required techniques; however, they must be willing to expand their technical and scientific capabilities
Expertise in multiparameter flow cytometry, transcriptional analyses, ex vivo mouse tissue processing, in vivo syngeneic/GEM tumor models
Experience in mouse handling and primary cell tissue harvest
Expertise in mouse and human tumor cell culture
Scientific and technical knowledge of mRNA-LNP technology
Significant molecular biology experience including CRISPR-mediated deletion of genes and overexpression of model antigens in mouse syngeneic tumor cell lines
Expertise in bulk and single cell RNA-Seq, ELISA, and Western blot experimentation and analyses
OTHER JOB DETAILS
Eligible for Relocation Assistance
Must Have Work Authorization in US
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer.