Postdoctoral position
- UF SCRIPPS BIOMEDICAL RESEARCH
- Location: Jupiter, FL
- Job Number: 7110908
- Posting Date: Sep 17, 2022
- Application Deadline: Open Until Filled
Job Description
The Subramaniam group at UF Scripps Biomedical Research in Florida, USA, is seeking postdoctoral candidates to study protein transmission and ribosome stalling mechanisms in neurodegenerative diseases.
The Subramaniam lab's primary goal is to understand the nuances of cellular and molecular processes involved in striatal functioning and how their dysfunction increases susceptibility to neurological disorders, with a particular emphasis on Huntington disease, Alzheimer disease and Parkinson disease. To learn more about Subramaniam Lab research, please visit https://subramaniam.scripps.ufl.edu/
Potential postdoctoral candidates should know biochemical, cellular, and molecular biology techniques. Experience in neurodegenerative research is not required, although prior knowledge of ribosome biology, protein biochemistry, and mice studies is advantageous. Postdoctoral candidates should have published research, strong drive and professional goals, and the capacity to work independently and collaboratively.
UF Scripps Biomedical Research is in Jupiter, Florida, USA https://www.jupiter.fl.us/ a town community bolstered by the Max Planck Institute of Neuroscience and Florida Atlantic University's Brain Research Institute. Aside from cutting-edge core facilities and research laboratories, UF Scripps provides competitive perks and career-development opportunities. https://scripps.ufl.edu/
For consideration, suitable candidates should email a cover letter, complete CV, and research experience with referees (up to 3) information to Dr. Srini Subramaniam: [email protected] as a single PDF.
Selected References from Subramaniam lab:
1. Eshraghi, M., et al., Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease. Nat Commun, 2021. 12(1): p. 1461.
2. Subramaniam, S., Ribosome traffic jam in neurodegeneration: decoding hurdles in Huntington disease. Cell Stress, 2021. 5(6): p. 86-88.
3. Subramaniam S, S.N., Ribosome Profiling Reveals a Dichotomy Between Ribosome Occupancy of Nuclear-Encoded and Mitochondrial-Encoded OXPHOS mRNA Transcripts in a Striatal Cell Model of Huntington Disease. BioRXiv (Pre Print), 2021.
4. Park S, R.-J.U., Shahani N, Rivera O, Sharma M, McManus FP, Thibault P, Subramaniam S, SUMO Modifies GβL and Mediates mTOR Signaling. BioRxiv, 2020.
5. Ramirez-Jarquin, U.N., et al., Rhes protein transits from neuron to neuron and facilitates mutant huntingtin spreading in the brain. Sci Adv, 2022. 8(12): p. eabm3877.
6. Ramirez-Jarquin, U.N., et al., Deletion of SUMO1 attenuates behavioral and anatomical deficits by regulating autophagic activities in Huntington disease. Proc Natl Acad Sci U S A, 2022. 119(5).
7. Sharma, M., et al., Rhes, a striatal-enriched protein, promotes mitophagy via Nix. Proc Natl Acad Sci U S A, 2019. 116(47): p. 23760-23771.
8. Sharma, M., et al., Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease. Proc Natl Acad Sci U S A, 2020. 117(27): p. 15989-15999.
9. Sharma, M. and S. Subramaniam, Rhes travels from cell to cell and transports Huntington disease protein via TNT-like protrusion. J Cell Biol, 2019. 218(6): p. 1972-1993.
10. Uri Nimrod Ramirez Jarquin, M.S., Neelam Shahani, Yunqing Li, Siddaraju Boregowda, Srinivasa Subramaniam, Rhes protein transits from neuron to neuron and facilitates mutant huntingtin spreading in the brain. Sci Adv, 2022.
The Subramaniam lab's primary goal is to understand the nuances of cellular and molecular processes involved in striatal functioning and how their dysfunction increases susceptibility to neurological disorders, with a particular emphasis on Huntington disease, Alzheimer disease and Parkinson disease. To learn more about Subramaniam Lab research, please visit https://subramaniam.scripps.ufl.edu/
Potential postdoctoral candidates should know biochemical, cellular, and molecular biology techniques. Experience in neurodegenerative research is not required, although prior knowledge of ribosome biology, protein biochemistry, and mice studies is advantageous. Postdoctoral candidates should have published research, strong drive and professional goals, and the capacity to work independently and collaboratively.
UF Scripps Biomedical Research is in Jupiter, Florida, USA https://www.jupiter.fl.us/ a town community bolstered by the Max Planck Institute of Neuroscience and Florida Atlantic University's Brain Research Institute. Aside from cutting-edge core facilities and research laboratories, UF Scripps provides competitive perks and career-development opportunities. https://scripps.ufl.edu/
For consideration, suitable candidates should email a cover letter, complete CV, and research experience with referees (up to 3) information to Dr. Srini Subramaniam: [email protected] as a single PDF.
Selected References from Subramaniam lab:
1. Eshraghi, M., et al., Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease. Nat Commun, 2021. 12(1): p. 1461.
2. Subramaniam, S., Ribosome traffic jam in neurodegeneration: decoding hurdles in Huntington disease. Cell Stress, 2021. 5(6): p. 86-88.
3. Subramaniam S, S.N., Ribosome Profiling Reveals a Dichotomy Between Ribosome Occupancy of Nuclear-Encoded and Mitochondrial-Encoded OXPHOS mRNA Transcripts in a Striatal Cell Model of Huntington Disease. BioRXiv (Pre Print), 2021.
4. Park S, R.-J.U., Shahani N, Rivera O, Sharma M, McManus FP, Thibault P, Subramaniam S, SUMO Modifies GβL and Mediates mTOR Signaling. BioRxiv, 2020.
5. Ramirez-Jarquin, U.N., et al., Rhes protein transits from neuron to neuron and facilitates mutant huntingtin spreading in the brain. Sci Adv, 2022. 8(12): p. eabm3877.
6. Ramirez-Jarquin, U.N., et al., Deletion of SUMO1 attenuates behavioral and anatomical deficits by regulating autophagic activities in Huntington disease. Proc Natl Acad Sci U S A, 2022. 119(5).
7. Sharma, M., et al., Rhes, a striatal-enriched protein, promotes mitophagy via Nix. Proc Natl Acad Sci U S A, 2019. 116(47): p. 23760-23771.
8. Sharma, M., et al., Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease. Proc Natl Acad Sci U S A, 2020. 117(27): p. 15989-15999.
9. Sharma, M. and S. Subramaniam, Rhes travels from cell to cell and transports Huntington disease protein via TNT-like protrusion. J Cell Biol, 2019. 218(6): p. 1972-1993.
10. Uri Nimrod Ramirez Jarquin, M.S., Neelam Shahani, Yunqing Li, Siddaraju Boregowda, Srinivasa Subramaniam, Rhes protein transits from neuron to neuron and facilitates mutant huntingtin spreading in the brain. Sci Adv, 2022.
