Postdoctoral Fellowships in Musculoskeletal Disease
- University of California San Francisco
- Location: San Francisco, CA
- Job Number: 7117041
- Posting Date: Nov 30, 2022
- Application Deadline: Open Until Filled
The Hsiao and Wentworth labs at the University of California in San Francisco, CA USA, has Postdoctoral Fellow positions available for scientists interested in musculoskeletal basic/translational human research.
Our labs use the skeletal system as a basis for understanding how hormonal and genetic factors affect human development and disease. We use a wide spectrum of approaches to develop a broader understanding of the biology underlying skeletal development, develop new models for studying disease pathology and how other organs interact with the skeleton, and devise novel therapeutic approaches.
The successful candidates will have the opportunity to lead integrated research projects in these areas as part of a basic/translational research team:
Postdoctoral fellowship in human iPS cell modeling of inflammation and bone disease: This project involves the use of human iPS cells to model inflammatory and neurologic contributors to abnormal bone formation, and the identification of potential molecular targets for blocking excessive bone formation. We are also using human iPS cells to understand how different signaling pathways, such as BMPs and GPCRs, regulate osteogenesis and using iPS cells to create microphysiologic models of disease. Candidates should have extensive, demonstrable experience in cellular and molecular biology methods including stem cell culture. Computational experience with single cell or RNAseq analysis is also preferred (including experience with R and python). Experience with mouse imaging (microCT), histologic analyses, and surgeries is also highly preferred.
Postdoctoral fellowship in human microbiome as a modifier of heterotopic ossification: This project uses human specimens and mouse models to understand how the gut microbiome impacts heterotopic ossification, a situation where bone forms at an inappropriate site and often in response to inflammation. Projects will involve the derivation and study of human iPS cell-derived lineages such as macrophages, and understanding how these critical lineages contribute to human bone formation after injury (such as heterotopic ossification) and are modulated by the microbiome. Candidates should have extensive, demonstrable experience in cellular and molecular biology methods and mouse work. Computational experience with microbiome metabologenomic and metabolomic analyses is highly preferred (including experience with R and python). Experience with mouse imaging (microCT) and histology is also highly preferred.
Postdoctoral fellowship in G-protein coupled receptor (GPCR) signaling in musculoskeletal diseases: This project uses human specimens and mouse models to understand how the abnormal activation of the Gs-GPCR signaling pathway drives abnormal bone formation. Projects will involve the use of human iPS cells and mouse models to identify impinging pathways that could be targeted as therapies; using digital spatial profiling and high throughput sequencing to understand the requirement for mosaicism in disease pathogenesis; and screening compounds for activity in the Gs-GPCR pathway. Candidates should have extensive, demonstrable experience in cellular and molecular biology methods and mouse work, and be comfortable with sequencing analysis. Experience with mouse imaging analyses (microCT), FACS, and high throughput compound screening are also highly preferred.
All positions require excellent written and verbal communication skills. Within our diverse community, strong teaching and mentoring experience is expected for leadership of the research teams. The candidate must be highly motivated, responsible, creative, personable, and work well in a highly collaborative environment.
The Hsiao and Wentworth labs are part of the Division of Endocrinology and Metabolism in the Department of Medicine at the University of California, San Francisco. We have a strong dedication to mentoring, intellectual discovery, and career development, in a supportive yet independent environment. We are members of the Institute for Human Genetics, the Biomedical Sciences graduate program, the Program in Craniofacial Biology, the UCSF Benioff Center for Microbiome Medicine, and the UCSF Diabetes Center. The Hsiao lab is centrally located with easy access to many facilities and collaborators.
UCSF is a world-class research and medical institution with state-of-the-art facilities and services. The UCSF Endocrine program is ranked #6 in the United States and #1 in California by the 2022 US News and World Report. San Francisco is also home to a thriving research community with multiple academic institutions and cutting-edge biotechnology companies nearby. San Francisco is a vibrant place to live, with wonderful opportunities to enjoy the outdoors, hiking, skiing/snowboarding, nightlife, food, arts, and much more.
Please contact [email protected] or [email protected] for further information. Please send your CV, a statement of your prior research experience, your research interests, and career goals.
The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.