Postdoctoral Fellow
- Sidney Kimmel Cancer Center at Thomas Jefferson University
- Location: Philadelphia, PA
- Job Number: 7119458
- Posting Date: Jan 5, 2023
- Application Deadline: Open Until Filled
Job Description
We are seeking a Postdoctoral Fellow to join our research program on understanding how cellular stress adaptation and stress granules contribute to pancreatic cancer. Our research ranges from fundamental molecular mechanisms and organelle biology to clinical applications utilizing high-resolution imaging, molecular and cellular biology, 3D cell culture, flow cytometry, omics studies, and mouse models. A major goal of the lab is to study how obesity promotes of tumorigenesis and the role of stress granules in this process and in the reprogramming of the immune microenvironment. For more information please visit our website: www.grabockalab.com
Examples of our work can be found here:
Fonteneau G, Redding A, Hoag-Lee H, Sim ES, Heinrich S, Gaida MM, Grabocka E. Stress Granules Determine the Development of Obesity-Associated Pancreatic Cancer. Cancer Discov. 2022 Aug 5;12(8):1984-2005. doi: 10.1158/2159-8290.CD-21-1672. PMID: 35674408; PMCID: PMC9357213.
Redding A, Aplin AE, and Grabocka E. RAS-mediated tumor stress adaptation and the targeting opportunities it presents. Dis Model Mech. 2022 Feb 1;15(2): dmm049280. doi: 10.1242/dmm.049280. Epub 2022 Feb 11. PMID: 35147163.
Song Min-Seok and Grabocka E. Stress Granules in Cancer. Rev Physiol Biochem Pharmacol. 2020 Aug 14
Grabocka E and Bar-Sagi D. Mutant KRAS enhances tumor cell fitness by upregulating stress granules. Cell. 2016 Dec 15;167(7):1803-1813.e12.
Requirements
Candidates should have a recent PhD or MD/PhD degree in cancer biology, cancer immunology, cell biology, biochemistry, or a closely related field. Prior experiences with imaging, flow cytometry, proteomics, and animal work are preferred. Successful candidates will join a highly motivated, engaging, and energetic research group and a diverse and supportive research community at the Sidney Kimmel Cancer Center at Thomas Jefferson University.
Interested applicants should submit a cover letter explaining their scientific interest, their previous experience, and a CV to Dr. Elda Grabocka at [email protected]. Please include the contact information for three references in the last page of the CV.
Examples of our work can be found here:
Fonteneau G, Redding A, Hoag-Lee H, Sim ES, Heinrich S, Gaida MM, Grabocka E. Stress Granules Determine the Development of Obesity-Associated Pancreatic Cancer. Cancer Discov. 2022 Aug 5;12(8):1984-2005. doi: 10.1158/2159-8290.CD-21-1672. PMID: 35674408; PMCID: PMC9357213.
Redding A, Aplin AE, and Grabocka E. RAS-mediated tumor stress adaptation and the targeting opportunities it presents. Dis Model Mech. 2022 Feb 1;15(2): dmm049280. doi: 10.1242/dmm.049280. Epub 2022 Feb 11. PMID: 35147163.
Song Min-Seok and Grabocka E. Stress Granules in Cancer. Rev Physiol Biochem Pharmacol. 2020 Aug 14
Grabocka E and Bar-Sagi D. Mutant KRAS enhances tumor cell fitness by upregulating stress granules. Cell. 2016 Dec 15;167(7):1803-1813.e12.
Requirements
Candidates should have a recent PhD or MD/PhD degree in cancer biology, cancer immunology, cell biology, biochemistry, or a closely related field. Prior experiences with imaging, flow cytometry, proteomics, and animal work are preferred. Successful candidates will join a highly motivated, engaging, and energetic research group and a diverse and supportive research community at the Sidney Kimmel Cancer Center at Thomas Jefferson University.
Interested applicants should submit a cover letter explaining their scientific interest, their previous experience, and a CV to Dr. Elda Grabocka at [email protected]. Please include the contact information for three references in the last page of the CV.
