Post-doctoral fellowships in cancer chemical biology and computational biology
- Massachusetts General Hospital Cancer Center & Harvard Medical School
- Location: Boston, MA
- Job Number: 7126605
- Posting Date: Feb 24, 2023
Job Description
Post-doctoral fellowships are available in the Ott Laboratory (ottlab.org) at the Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School - Boston, MA, United States. We are a team of dedicated scientists that use the disciplines of computational biology, chemistry, and functional genetics to define gene regulatory targets for cancer. Specifically, we are interested in developing early-stage chemical probes to target essential chromatin and transcriptional modulators in blood cancers. We foster a rigorous, exciting, supportive environment for training the next generation of cancer researchers.
Position 1: Chemical/molecular biology of essential gene regulatory factors in cancer
The lab is recruiting a post-doctoral molecular or chemical biologist with a significant interest in using functional and chemical genetics to probe the essential gene regulatory factors in cancer. The ideal candidate(s) will have a Ph.D., M.D., or M.D./Ph.D. in molecular biology, pharmacology, oncology, or related discipline. Familiarity with computational tools useful for genomics and epigenomics research is desirable. Available projects in the lab include understanding mechanisms of cancer cell dependency on lineage-defining gene regulatory factors and associated epigenetic machinery, high-throughput assay design and screening for novel chemical probes, functional genetic screening with gene and epigenome editing technology to identify new therapeutic targets, and genome-wide chromatin structure analysis to understand gene regulatory malfunction in cancer.
Position 2: Computational biology studying gene regulatory circuitry in cancer
The lab is recruiting a post-doctoral computational-based scientist with a significant interest in using computational tools to probe the essential gene regulatory factors in cancer. The ideal candidate(s) will have a Ph.D., M.D., or M.D./Ph.D. in computational biology or related discipline. Expertise with one or more of the following is desired: analysis of 3-dimensional chromosome conformation datasets (HiC, HiChIP), genome-wide epigenomics/transcriptomics datasets (ChIP-seq, ATAC-seq, RNA-seq, single-cell omics).
These positions require a high level of self-motivation, excellent communication skills, and the ability to work diligently and cooperatively with others. Successful applicants will be able to work independently, maintain high standards of laboratory safety, and display the intellectual curiosity required to effectively lead multidisciplinary projects. Example publications for further information on our current work: Vannam et al, Cell Chemical Biology 2021; Ott et al, Cancer Cell 2018.
Interested candidates should send a cover letter, CV, and the contact details of three references directly to:
Christopher Ott, PhD
[email protected]
Position 1: Chemical/molecular biology of essential gene regulatory factors in cancer
The lab is recruiting a post-doctoral molecular or chemical biologist with a significant interest in using functional and chemical genetics to probe the essential gene regulatory factors in cancer. The ideal candidate(s) will have a Ph.D., M.D., or M.D./Ph.D. in molecular biology, pharmacology, oncology, or related discipline. Familiarity with computational tools useful for genomics and epigenomics research is desirable. Available projects in the lab include understanding mechanisms of cancer cell dependency on lineage-defining gene regulatory factors and associated epigenetic machinery, high-throughput assay design and screening for novel chemical probes, functional genetic screening with gene and epigenome editing technology to identify new therapeutic targets, and genome-wide chromatin structure analysis to understand gene regulatory malfunction in cancer.
Position 2: Computational biology studying gene regulatory circuitry in cancer
The lab is recruiting a post-doctoral computational-based scientist with a significant interest in using computational tools to probe the essential gene regulatory factors in cancer. The ideal candidate(s) will have a Ph.D., M.D., or M.D./Ph.D. in computational biology or related discipline. Expertise with one or more of the following is desired: analysis of 3-dimensional chromosome conformation datasets (HiC, HiChIP), genome-wide epigenomics/transcriptomics datasets (ChIP-seq, ATAC-seq, RNA-seq, single-cell omics).
These positions require a high level of self-motivation, excellent communication skills, and the ability to work diligently and cooperatively with others. Successful applicants will be able to work independently, maintain high standards of laboratory safety, and display the intellectual curiosity required to effectively lead multidisciplinary projects. Example publications for further information on our current work: Vannam et al, Cell Chemical Biology 2021; Ott et al, Cancer Cell 2018.
Interested candidates should send a cover letter, CV, and the contact details of three references directly to:
Christopher Ott, PhD
[email protected]
