About City of Hope

City of Hope is an independent biomedical research and treatment organization for cancer, diabetes and other life-threatening diseases.

Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope’s translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution. AccessHope™, a subsidiary launched in 2019 serves employers and their health care partners by providing access to City of Hope’s specialized cancer expertise.

A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation’s “Best Hospitals” in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.

City of Hope’s commitment to Diversity, Equity and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all of our communities. Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds and experiences to our work -- and that our teams align with the people we serve in order to build trust and understanding. We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds and perspectives; this is reflected in our work and represented in our people.

Position Summary

We are looking for a talented and highly motivated Postdoctoral Fellow, to join the Laboratory for Cellular Medicine (LCM), Center for Gene Therapy at the Beckman Research Institute of City of Hope. The candidate will join a well-established group performing cutting-edge research, development and qualification of large-scale processes, and manufacture of products for gene therapy clinical trials, including first-in-human studies with genetically engineered (ge) hematopoietic stem and progenitor cells (HSPC) and T cells.

Key Responsibilities include:

• Conduct research on next-generation targeted gene modification of human HSPC and iPSC, on strategies to modulate stemness and on the development of niche-mimetics.
• Interact with the Process Development team and will participate in the optimization of methods for efficient gene-modification of target cells and their transfer into clinical-scale manufacture processes, as well as in the development and qualification of project-specific potency and identity assays for release and characterization of these therapeutic products.
• Fellows are expected to perform high quality original research work, participate in the clinical translation of their work, prepare manuscripts for publication, contribute to extramural grant applications and the preparation of progress reports for funding agencies, and to submit relevant postdoctoral fellowship applications.

Basic education, experience and skills required for consideration:

• PhD or MD/PhD in biological sciences with a strong interest in translational research. Preference will be given to candidates with expertise in the study of hematopoiesis and biology of HSPC, experimentation with primary human cells and iPSC, and gene editing and viral transduction.
• Expertise in cell selection, hematopoietic functional assays, multiparametric flow cytometry, PCR, and basic knowledge of molecular biology, are required.
• Excellent communication skills.
• The ability to work independently, to participate in highly collaborative projects, and to contribute intellectually to the development of the research and process development are requisites for this position.
• Appreciate working in multi-disciplinary teams and to take on challenging projects are particularly encouraged to apply.

Additional Information:

• As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.
• For more information on Dr. Angelo Cardoso’s research, please visit here.