About City of Hope

City of Hope is an independent biomedical research and treatment organization for cancer, diabetes, and other life-threatening diseases.

Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope’s translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin, monoclonal antibodies and numerous breakthrough cancer drugs are based on technology developed at the institution. AccessHope™, a subsidiary launched in 2019 serves employers and their health care partners by providing access to City of Hope’s specialized cancer expertise.

A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked among the nation’s “Best Hospitals” in cancer by U.S. News & World Report and received Magnet Recognition from the American Nurses Credentialing Center. Its main campus is located near Los Angeles, with additional locations throughout Southern California and in Arizona.

City of Hope’s commitment to Diversity, Equity, and Inclusion

We believe diversity, equity and inclusion is key in serving our mission to provide compassionate patient care, drive innovative discovery, and advance vital education focused on eliminating cancer and diabetes in all our communities. Our commitment to Diversity, Equity and Inclusion ensures we bring the full range of skills, perspectives, cultural backgrounds, and experiences to our work -- and that our teams align with the people we serve to build trust and understanding. We are dedicated to fostering a community that embraces diversity - in ideas, backgrounds, and perspectives; this is reflected in our work and represented in our people.

Position Summary

A Postdoctoral Fellowship opportunity is immediately available for the highly motivated individual in the laboratory of Dr. Ya-Huei Kuo, at the Beckman Research Institute of City of Hope, a prestigious NCI-designated Comprehensive Cancer Center.

The candidate will directly work on identifying mechanisms contributing to leukemia pathogenesis, immune evasion and therapy resistance; developing novel leukemia therapeutics; and participate in a multidisciplinary team work to study information flow and state-transition at multi-dimensional scales.

The research goals in the Kuo laboratory are to discover mechanisms of leukemogenesis and leukemia stem cell persistence; to develop mechanism-based targeted therapeutics; and to deliver useful tools to monitor and predict disease progression or therapy response. The laboratory utilizes genetic mouse models and patient-derived xenografts of leukemia combined with cell culture, biochemistry, functional genomics, high-throughput sequencing and mathematical modeling approaches.

Skills that are used in the lab include: flow cytometry, biochemistry, cell culture, metabolic assays, molecular cloning, viral vector packaging, cell transduction, mouse handling (transplantation, drug treatment, blood collection).

Basic education, experience and skills required for consideration:

· PhD or M.D.

· Experience working with mice.

· Experience in multi parameter flow cytometry, biochemistry, molecular/cell biology techniques.

· Strong communication skills and collaborative mindset

As a condition of employment, City of Hope requires staff to comply with all state and federal vaccination mandates.

· For more information on Dr. Ya-Huei Kuo’s work please visit here