Postdoctoral Fellow - Lymphoid Malignancies
- City of Hope
- Location: Duarte, CA
- Job Number: 7157583 (Ref #: 10022022)
- Posting Date: Apr 9, 2024
- Salary / Pay Rate: $31.00 - $34.23 / hour
- Application Deadline: Open Until Filled
Job Description
Join the forefront of groundbreaking research at theBeckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.
We are seeking a talented and motivated Postdoctoral Fellow to work in the laboratory of Dr. Srividya Swaminathan in the Department of Systems Biology at City of Hope. We study processes within lymphocytes and those outside (in the immune microenvironment) that drive the development of lymphoid malignancies including B- and T- cell acute lymphoblastic leukemia (ALL) and lymphomas. We apply this to develop therapies that specifically target malignant lymphocytes. Research in our lab spans Hematology, Oncology, and Immuno-Oncology. The Postdoctoral Fellow who joins the team will lead a project focused on specifically targeting diseased immune subsets in systemic lupus erythematosus (SLE) and indolent lymphomas. The Fellow will perform experiments using transgenic and transplantation mouse models of lymphoproliferative diseases, primary cells from patients, humanized mice, gene editing, classical molecular, cell biology, and biochemistry, and single cell sequencing approaches. The Fellow will also contribute to other ongoing immuno-oncology projects in the team.
As a successful candidate, you will use the following methods:
- Immune profiling (cytometry, scRNAseq).
- In vivo assays (mouse genetics, intravenous and intrafemoral transplantation assays, subcutaneous pump implantation for delivery of candidate therapies, humanized mouse models, pre-clinical testing of immunotherapies in xenotransplantation models, bioluminescence imaging).
- Molecular biology and biochemistry (retroviral/lentiviral transduction, molecular cloning, high throughput RNA/DNA sequencing, qPCR, immunoblotting, immunofluorescence, Luminex, CRISPR-based gene editing of immune cells).
Your qualifications should include:
- PhD in Immunology, Cell, Molecular biology, or another field related to Life Sciences. Experience with flow cytometry.
- Experience performing in vivo procedures in mice.
City of Hope is an equal opportunity employer. To learn more about our commitment to diversity, equity and inclusion, please click here.
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Salary / Pay Rate Information:
Pay Rate: $31.00 - $34.23 / hour
The estimated pay scale represents the typical [salary/hourly] range City of Hope reasonably expects to pay for this position, with offers determined based on several factors which may include, but not be limited to, the candidate’s experience, expertise, skills, education, job scope, training, internal equity, geography/market, etc. This pay scale is subject to change from time to time.
City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.
