- University of California, San Francisco (UCSF)
- Location: San Francisco, CA
- Job Number: 7180190
- Posting Date: Sep 19, 2023
- Application Deadline: Open Until Filled
We have a long-standing interest in elucidating the molecular mechanisms of lung development, repair/regeneration, and tumorigenesis. These studies aim to establish the foundation for treating human diseases such as chronic obstructive lung disease (COPD) and lung cancer. To this end, we use the mouse as a model system and also take advantage of normal and diseased human lung tissues. We combine mouse genetics, cell biology, genomic analysis, CRISPR technology, proteomics, and lung organoids to address central questions in alveolar formation and repair, and the pathogenesis of lung cancer development. Our research program holds the promise of translating discovery from bench to bedside.
Candidates are expected to have a PhD or MD degree and research experience in molecular and cell biology and preferably experience using mouse models.
Please send CV, brief statement of research interests and names of three references to:
Dr. Pao-Tien Chuang
Cardiovascular Research Institute
University of California, San Francisco
E-mail: [email protected]
Lab website: https://sites.google.com/view/chuanglab/
The University of California is an equal opportunity employer.
1. Zhang K, Yao E, Chuang E, Chen B, Chuang E, Chuang, PT. mTORC1 signaling facilitates differential stem cell differentiation to shape the developing murine lung and is associated with mitochondrial capacity. Nat Commun. 2022 Nov 25;13(1):7252. doi: 10.1038/s41467-022-34763-y. PMID: 36433959; PMCID: PMC9700781.
2. Zhang K, Yao E, Chuang E, Chen B, Chuang EY, Volk RF, Hofmann KL, Zaro B, Chuang PT. Wnt5a-Vangl1/2 signaling regulates the position and direction of lung branching through the cytoskeleton and focal adhesions. PLoS Biol. 2022 Aug 26;20(8):e3001759. doi: 10.1371/journal.pbio.3001759. PMID: 36026468; PMCID: PMC9469998.
3. Zhang K, Yao E, Wang SA, Chuang E, Wong J, Minichiello L, Schroeder A, Eckalbar W, Wolters PJ, Chuang PT. A functional circuit formed by the autonomic nerves and myofibroblasts controls mammalian alveolar formation for gas exchange. Dev Cell. 2022 Jul 11;57(13):1566-1581.e7. doi: 10.1016/j.devcel.2022.05.021. Epub 2022 Jun 16. PMID: 35714603; PMCID: PMC9308505.
4. Zhang K, Yao E, Chen B, Chuang E, Wong J, Seed RI, Nishimura SL, Wolters PJ, Chuang PT. Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria. Elife. 2022 Apr 6;11:e68598. doi: 10.7554/eLife.68598. PMID: 35384838; PMCID: PMC9183236.
5. Zhang K, Yao E, Lin C, Chou YT, Wong J, Li J, Wolters PJ, Chuang PT. A mammalian Wnt5a-Ror2-Vangl2 axis controls the cytoskeleton and confers cellular properties required for alveologenesis. Elife. 2020 May 12;9:e53688. doi: 10.7554/eLife.53688. PMID: 32394892; PMCID: PMC7217702.