Postdoctoral Associate | Robson Lab
- The Jackson Laboratory for Genomic Medicine
- Location: Farmington, CT
- Job Number: 7194796 (Ref #: JR004194)
- Posting Date: Nov 17, 2023
Postdoctoral Associate | SenNet Tissue Mapping Center
The Robson lab is seeking an independent, highly motivated PhD-level scientist (<2 years postdoc experience) to join our efforts as a Tissue Mapping Center (TMC) in the NIH Common Fund’s Cellular Senescence Network (SenNet) Program (https://sennetconsortium.org). The overarching goal of this Program is to identify and characterize senescence cells in intact human and mouse tissues. We employ advanced tissue mapping technologies inclusive of single cell RNA-seq, spatial transcriptomics, multiplexed in situ analysis, and multiplexed antibody-based imaging. In addition, we use human iPSC-derived cellular systems to model developmental senescence in a dish. Target tissues for our TMC include the placenta (for developmental senescence), kidney, pancreas, and adipose tissue. The ideal candidate would have a strong background in cell and molecular biology and tissue physiology. The individual would work within the Biological Analysis Core of our SenNet TMC and be responsible for implementing (from design to execution) tissue mapping approaches working closely with the expert scientific staff within the Single Cell Biology Laboratory Scientific Service. In addition, the individual would be involved in the interpretation and analysis of the resulting data, working closely with the Data Analysis Core of our SenNet TMC. As part of the SenNet Program, this talented individual would have access to a world-class consortium of experts in tissue mapping technologies and senescence biology. Regular interactions and presentations within the larger SenNet Program is expected.
Dr. Robson oversees the single cell and tissue mapping capabilities of The Jackson Laboratory as a whole and, within his own research program at The Jackson Laboratory for Genomic Medicine, has specific interests in early embryonic development, in vitro cellular modeling of human biology, and how the biology of early development (and the placenta) may provide insight into and/or impact later in life biology (e.g., solid tumor biology, senescence) through the pleiotropic effect of genes undergoing natural selection at these early post-fertilization stages.
- Ph.D. in cell biology, molecular biology, developmental biology or related field of study.
- Prior research experience in at least two of the following areas: pluripotent stem cell biology and differentiation, cellular physiology, next-generation genome sequencing assays, tissue analysis inclusive of extensive antibody-based imaging approaches.
- Experience in single cell technologies for transcriptomics, flow cytometry (or other forms of cytometric analyses), cellular histology and image analysis is particularly desirable.
- Candidates should have a publication record in peer-reviewed journals.
- Excellent writing and communication skills, able to work independently and effectively with other members in a productive team.
- Experience with R, Python or similar statistical package in the context of genomic data analyses and bioinformatics is an asset.
The Jackson Laboratory is an independent, nonprofit biomedical research institution with a National Cancer Institute-designated Cancer Center and nearly 3,000 employees in locations across the United States (Maine, Connecticut, California), Japan and China. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.
Founded in 1929, JAX applies over nine decades of expertise in genetics to increase understanding of human disease, advancing treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease. It models and interprets genomic complexity, integrates basic research with clinical application, educates current and future scientists, and provides critical data, tools and services to the global biomedical community. For more information, please visit www.jax.org.
The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws.