Are you a hardworking and dedicated research professional interested in being part of breakthrough Research?

When you join Cedars-Sinai, you become part of a team that is at the forefront of medical advancements and life-saving medical and scientific breakthroughs. Cedars-Sinai is one of the leading institutes for driven research funding from the National Institutes of Health. As an international leader in biomedical research, we translate discoveries into successful treatments with global impact.

Principal Investigator, Caroline Jefferies, PhD is searching for a Research Associate II to join the team!

The research of Caroline Jefferies, PhD, is focused on understanding the role that RNA/DNA sensing mechanisms in monocytes and neutrophils play in driving autoimmune disease. The lab’s main area of focus is understanding these pathways in lupus, a debilitating, chronic autoimmune disease that presents as a broad spectrum of symptoms and manifestations.

The Jefferies Lab seeks a Research Associate II with an interest in performing routine and increasingly complex laboratory tasks and procedures. The RA II will develop technical expertise in one or more areas relevant to research projects and will participate in research activities involving all aspects of the research process, to include, but not limited to; investigation, technical, testing/validation of results, and report findings. The Associate will perform a variety of routine experimental protocols and procedures to support the objectives of laboratory research projects. The incumbent will observe and comply with safety standards and procedures, assist in preparation of data for publication and/or presentation at scholarly meetings, and assist in general laboratory maintenance. This position does not have supervisory responsibilities.

Primary Duties and Responsibilities:

• Assists with the design of new complex or unusual protocols and techniques.
• Keeps accurate and detailed records of experiments and results and helps in identifying and troubleshooting of unexpected results.
• Orders laboratory supplies and supports laboratory operations.
• Maintains lab equipment and related records and may coordinate use of lab equipment.
• Assists in the operation of specialized equipment, as required by the area of research.
• Orients Research Laboratory Assistants or lower-level Research Associates and undergraduate student researchers on day-to-day lab operations and routine procedures.

Department-Specific Duties:

The incumbent will work with a team to characterize UV-induced skin disease in animal models on the following:

• Conducting animal experiments to assess how UV contributes to skin disease in Lupus.
• Setting up models to assess lung inflammation in lupus – including air liquid interface cultures, making precision cut lung slices to analyze inflammation.
• Using co-immunoprecipitation and western blotting to look at protein-protein interactions and post-translational modifications of proteins.
• Other laboratory analysis as appropriate such as RT-PCR, IF, and Western blotting.

Education:

• Bachelor's degree in a Science related field, required.

Experience and Skills:

• One year of laboratory experience, required.
• Immunology or cell biology lab experience preferred.
• Experience with routine laboratory procedures, experimental protocols, and overall lab organization.
• Ability to work independently.
• Must have outstanding interpersonal, communication and organization skills to work across company subject areas and functional units, and computer application experience.
• Must possess digital literacy in Excel and Word.
• Ability to simultaneously manage multiple tasks with attention to details.