The Charis Eng laboratory is seeking a highly motivated, self-driven postdoctoral research fellow for the Genomic Medicine Institute at Cleveland Clinic Lerner Research Institute. The successful candidate will have demonstrated proficiency in neurodevelopment and neuron-glial interaction research, mouse work and experiment design, and will apply those skills to elucidate the cellular and molecular mechanisms contributing to PTEN mutation-driven autism spectrum disorder observed in germline PTEN patients. The postdoctoral researcher will be directly responsible for conducting experiments and analyzing data under Dr. Eng’s mentorship and must be willing and able to work as part of a team, learn new techniques and mentor others.

The Genomic Medicine Institute is an interdisciplinary institute and department committed to performing translational and clinical human genetics and genomics investigation. A major focus of the Eng Lab is to utilize multi-disciplinary approaches – classical genetics, genomics, metagenomics, computational/systems biology, immunology, computational biophysics, animal modeling, and molecular biology – to elucidate the molecular mechanisms that contribute to cancer predisposition and neurodevelopmental disorders (e.g., autism spectrum disorder), and other PTEN-related phenotypes in the context of germline PTEN disruption.

Principal Investigator: Chris Eng, MD, PhD

Lerner Research Institute Department: Genomic Medicine Institute

Lab Research Topics:

• Neurodevelopment
• Mouse modeling for PTEN-Autism
• PTEN signaling mechanisms leading to autism
• Mechanisms bifurcating cancer vs autism outcomes in germline Pten mutation carriers
• Microglia
• For more information about the lab’s research, please visit: https://www.lerner.ccf.org/genomic-medicine/eng/#lab-investigator or contact Dr. Eng at [email protected].

Job Responsibilities:

• Independent project design with the goal of data generation, analysis, interpretation and manuscript preparation
• Provide clear, detailed and thorough progress reports
• Mouse genotyping, tissue collection
• Data analysis, presentation, manuscript preparation

Education:

• PhD or MD/PhD required
• MD with relevant laboratory experience may substitute for PhD

Languages:

• English Proficiency proof required for candidates arriving on J-1, J-2, or F1 + OPT visa status

Work Experience:

• Previous experience in a research or academic setting. Graduate student experience meets this requirement.
• Scientific writing experience

Additional Preferred Qualities:

• PhD required
• Knowledgeable in development and function of glia and neurons
• Proficient in Western blot, IF, ELISA, cell biology
• Good aseptic technique, and cell-culture experience
• Highly motivated and self-driven individual with exemplary work-ethic and ability to promote team-spirit/collegiality

Physical Requirements:

• Ability to perform work in a stationary position for extended periods
• Ability to operate a computer and other office equipment
• Ability to communicate and exchange accurate information
• Ability to distinguish color
• Manual dexterity to handle specimens and repair equipment
• Ability to lift and transport equipment or specimens weighing up to 20 pounds
• May be exposed to hazardous chemicals, bio-hazards, radioactive materials, etc.

Personal Protective Equipment:

• PPE per institutional requirements; may vary by laboratory

Preferred Application Materials:

• CV
• Research statement
• Name and contact of three references
• All application materials should be submitted directly via email to Dr. Charis Eng at [email protected].

Keywords: Postdoc, Research, LRI