Postdoctoral Fellow - Cancer Virology, T Cell Immunology, Structural Biology
- City of Hope
- Location: Duarte, CA
- Job Number: 7256621 (Ref #: 10026589)
- Posting Date: Aug 27, 2024
- Salary / Pay Rate: $34.00 - $37.55 / hour
- Application Deadline: Open Until Filled
Job Description
Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.
If you are looking for a challenging and exciting opportunity to advance your research career in cancer and virology, we invite you to join Dr. Javier Gordon Ogembo’s multi-disciplinary lab. Our lab is part of the Beckman Research Institute of City of Hope, a world-renowned National Comprehensive Cancer Center located just 20 miles from Los Angeles. City of Hope provides access to state-of-the-art facilities and resources excellent for transitional science, as well as a vibrant and collaborative research community. The Beckman Research Institute of City of Hope has several facilities that are approved by the FDA for the production of investigational drugs and biologics for use in clinical trials. These facilities are designed to meet rigorous regulatory standards and ensure the safety and efficacy of products developed at City of Hope.
For more information about Dr. Ogembo’s lab, please visit here.
As a successful candidate:
- You will have the opportunity to access state-of-the-art facilities and resources and work alongside leading experts in the field, contributing to cutting-edge research projects aimed at advancing our understanding the mechanisms of viral entry, oncovirology, vaccinology, and studying the interactions between viruses and host cells.
- In addition to the opportunity to work on exciting research projects, you will have access to City of Hope’s excellent benefits, and a supportive work environment that encourages career development and advancement.
Required qualifications:
- Ph.D., Ph.D/DVM, or MD/Ph.D degree(s) in a related field.
- Cell culture and aseptic technique: culture, handling, and maintenance of bacterial and mammalian cells (multiple cell lines), cryopreservation.
- Immuno-assays: western blot, ELISA, flow cytometry, immunofluorescence assay, immuno-histochemistry.
- Virology assays: virus production and titration, virus neutralization, plaque assays.
- DNA/RNA assays: DNA/RNA isolation from cells, viruses, and tissue, conventional PCR, qPCR, RT-qPCR, single cell RNA analysis.
- Pre-clinical animal models: animal handling (mice and/or rats), immunization/challenge, bodily fluid/blood collection, tissue processing.
- A track record of scientific productivity manifested in at least 2-3 first author publications in peer-reviewed journals.
- Ability to work independently and as part of a dynamic team.
- Previous experience working in a GLP/cGMP- compliant laboratory settings will be an added advantage.
Candidates must meet the required qualifications as well as possess the experience and techniques listed below for consideration into one of the four specialized areas in this lab:
Gamma-herpesvirus vaccine development:
- Experience with gammaherpesvirus biology, and/or developing, handling and characterizing mRNA/DNA, virus-like particles, viral vector, and/or nanoparticle vaccine candidates, including lipid nanoparticles formulations.
Gamma-herpesvirus T cell immunology and therapeutics:
- Immune cell assays: immune cell isolation (animal tissue, PBMCs), ex vivo T cell stimulation and proliferation assays, cell viability and metabolic activity assays, ELISPOT, cell migration assays, phagocytosis assays, multi-color flow cytometry immune panel analysis, and cytotoxicity assays.
Gamma-herpesvirus protein and antibody structural studies:
- Protein assays: protein production and purification, crystal structure, cryo-electron microscopy, nuclear magnetic resonance, circular dichroism (CD) spectroscopy, mass spectrometry, surface plasmon resonance.
Use of preclinical animal models to assess gamma-herpesvirus entry mechanism and vaccine development:
- Previous experience working with non-human primate samples.
- Previous experience working with the humanized mouse model.
City of Hope is an equal opportunity employer. To learn more about our commitment to diversity, equity and inclusion, please click here.
To learn more about our Comprehensive Benefits, pleaseCLICK HERE.
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Salary / Pay Rate Information:
Pay Rate: $34.00 - $37.55 / hour
The estimated pay scale represents the typical [salary/hourly] range City of Hope reasonably expects to pay for this position, with offers determined based on several factors which may include, but not be limited to, the candidate’s experience, expertise, skills, education, job scope, training, internal equity, geography/market, etc. This pay scale is subject to change from time to time.
City of Hope is a community of people characterized by our diversity of thought, background and approach, but tied together by our commitment to care for and cure those with cancer and other life-threatening diseases. The innovation that our diversity produces in the areas of research, treatment, philanthropy and education has made us national leaders in this fight. Our unique and diverse workforce provides us the ability to understand our patients' needs, deliver compassionate care and continue the quest for a cure for life-threatening diseases. At City of Hope, diversity and inclusion is a core value at the heart of our mission. We strive to create an inclusive workplace environment that engages all of our employees and provides them with opportunities to develop and grow, both personally and professionally. Each day brings an opportunity to strengthen our work, leverage our different perspectives and improve our patients’ experiences by learning from others. Diversity and inclusion is about much more than policies and campaigns. It is an integral part of who we are as an institution, how we operate and how we see our future.