A post-doctoral position is available in the laboratory of Dr. Silke Paust on or after November 18th 2024.

The research projects will focus on NK cell immunotherapy for chronic viral infection and cancers. Specifically, studies designed to investigate NK cell responses to HIV or solid tumors. The long-term goal of this project is to develop memory NK cell-based immunotherapies to prevent or cure these diseases by targeting immunosuppressive cells or pathways present in both diseases. This work will be performed using in humanized mice with a competent immune system and human specimens.

The successful candidate must be able to work independently, as well as in a team environment, pay close attention to detail and adhere to deadlines regularly. Excellent communication and interpersonal skills are essential. They will be detail-oriented, self-motivated, a fast learner, and possess excellent time management, organizational, written, and verbal communication skills. The ability to take direction and use independent judgment to meet experimental goals and deadlines is required. The successful candidate must be able to independently develop experimental protocols and approaches to troubleshooting experimental protocols, and perform advanced planning of experiment setups, data collection, and results for analysis. A strong commitment to experimental goals, career goals, and deadlines is required. Therefore, willingness to work into the evening and occasional weekend work is absolutely required. Prior post-doctoral experience is preferred for this position.

Required Qualifications:

• PhD in immunology, virology, or a related life science field, or a DVM or a related degree.
• Advanced immunology and NK cell biology expertise
• Experience with humanized mouse models of HIV disease or cancer (PDX)
• Sterile tissue culture and in vitro assays (killing assays, viral suppression assays, proliferation assays, etc.)
• Experience with multiparameter/digital flow cytometry and data analysis
• Standard molecular biology and biochemical techniques (qPCR, CRISPR)
• At least 2 year of BSL-2 laboratory techniques and BSL-2 animal model experience
• Peer reviewed first author publications resulting from graduate training

Preferred Qualifications:

• ~ 3 years of postdoctoral experience
• Peer reviewed first author publications from graduate training and postdoctoral training if applicable
• Mentoring experience

Positions require successful completion of required training courses, i.e. animal use, BL-2 safety, and general lab and chemical safety training.

About JAX:

The Jackson Laboratory is an independent, nonprofit biomedical research institution with a National Cancer Institute-designated Cancer Center and nearly 3,000 employees in locations across the United States (Maine, Connecticut, California),Japan andChina. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.

Founded in 1929, JAX applies over nine decades of expertise in genetics to increase understanding of human disease, advancing treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease. It models and interprets genomic complexity, integrates basic research with clinical application, educates current and future scientists, and provides critical data, tools and services to the global biomedical community. For more information, please visitwww.jax.org​​​​​​​.