Postdoctoral Fellow - Ligon Lab
- Dana-Farber Cancer Institute
- Location: Boston, MA
- Job Number: 7299354 (Ref #: df42964)
- Posting Date: Newly posted
Job Description
A Post Doctoral Research Fellow position is available in the laboratory of Dr. Keith Ligon in the fields of brain tumor biology and precision medicine. Prior experience in laboratory research is required. The position will involve the multidisciplinary study of cancer cell biology and mechanisms of treatment resistance in adult and pediatric gliomas. The position will involve use and training in a cutting edge techniques such as functional genomics (CRISPR screening), patient-derived human models of cancer, AI/ML methods in digital pathology and spatial biology analysis, human clinical trials. tissue biomarker analysis, genomics studies, stem cell culture, and development of high throughput screening methods for functional precision medicine. Skills or ability to apply computational approaches and implementation of bioinformatics methods is desired. Developing independence and will be fostered, and opportunities for intellectual input will also be readily available.
The Ligon lab environment is highly collaborative and there will be opportunities to interact with top-tier investigators and their teams in translational and basic science collaborations at the nation and international level. Fellows also have opportunity for joint appointments at the Broad Institute, Harvard Medical School, and Brigham and Womenâs Hospitals as projects require. Applicants will have excellent mentoring and training for academia and industry through projects in the lab and with external collaborators at the national and international level.
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
- Design, direction, and execution of research experiments to address problems in brain tumor biology and resistance to treatment
- In vitro cell culture and drug screening of human patient derived organoids/spheroids and models
- In vivo study, maintenance, and treatment of patient derived xenografts for evaluation of biology and therapeutics
- CRISPR engineering of patient models and screening
- Informatics analysis and interpretation of results from in vitro or in vivo assays (genomic sequencing, RNA sequencing)
- Use of spatial biology methods to examine tissue responses in models and patient samples
- Communication presentation of results at meetings and manuscript preparation
- Prior experience in lab research is preferred
- PhD, MD, MD/PhD or equivalent doctoral degree in biosciences, cancer biology, bioengineering, or a closely related field is required
- A minimum 2-year commitment is also requested.
At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff. Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.
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Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.
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