Post-doctoral fellow to develop synthetic gene expression switches expressed in CAR T Cells
- Seattle Children's Research Institute
- Location: Seattle, WA
- Job Number: 7322171
- Posting Date: Newly posted
- Salary / Pay Rate: 80,172/year
- Application Deadline: Open Until Filled
Job Description
This position will focus on developing synthetic gene expression switches expressed in CAR T Cells to overcome immune escape of tumors. Specific targets to accomplish this goal are informed by our two ongoing clinical trials treating patients with CAR T cells. The project will implement tumor triggered regulatory circuits to protect the engineered cells from exhaustion and enhance their survival with the tumor microenvironment.
The Heczey Lab believes that the development of the next-generation of cell therapies will be based on in-vivo (inside the body) genetic engineering of cells which can overcome the immune escape mechanisms employed within the tumor microenvironment to safely and effectively cure patients with cancer. The lab has a preclinical and clinical arm.
The post-doctoral associate will be part of an energetic team within the combined translational laboratories of the Ben Towne Center for Childhood Cancer and Blood Disorders Research at the Seattle Children’s Research Institution.
The post-doctoral associate will be tasked to design and conduct the experiments related to the project with the help of the mentor and other team members of the Heczey Lab. He/she will analyze the data and present the evolving results at weekly laboratory meetings and research seminars of the Seattle Children’s Research Institution. The details of the experiments and the findings will be recorded in electronic laboratory notebook.
Required Education and Experience
Doctorate degree (PhD/DVM/MD) in Immunology, genetic engineering, or related fields.
Experience using basic research techniques of specialty area.
Required Credentials: PhD
Preferred:
Great fund of knowledge of tumor immunology principles.
Understanding advanced genetic engineering techniques (transfection, retroviral / lentiviral transduction, transposition, CRISPR-Cas9).
Viral particle assembly.
Advanced cloning methods
Expertise in functional characterization of CAR T cells
Excellent aseptic cell culture technique.
Enthusiasm and a willingness to learn in a fast-pace, collaborative environment.
Strong organizational skills, record keeping, and interpersonal communication skills (verbal and written).
Compensation Range
$80,172/year
Salary Information: This compensation range was calculated based on full-time employment (2080 hours worked per calendar year). Offers are determined by multiple factors including equity, skills, experience, and expertise, and may vary within the range provided.
Benefits Information: Seattle Children’s offers a generous benefit package, including medical, dental, and vision plans, 403(b), life insurance, paid time off, tuition reimbursement, and more. Additional details on our benefits can be found on our website www.seattlechildrens.org/careers/benefits.
About Us
Hope. Care. Cure. These three simple words capture what we do at Seattle Children’s – to help every child live the healthiest and most fulfilling life possible. Are you ready to engage with a mission-driven organization that is life-changing to many, and touches the hearts of all? #HOPECARECURE
As one of the nation's top five pediatric research centers, Seattle Children's Research Institute is dedicated to providing hope, care, and cures to help every child live the healthiest and most fulfilling life possible.
Our investigators are involved in hundreds of projects that cover every phase of research, from studying how diseases work to improving investigational therapies. They have pioneered groundbreaking cystic fibrosis treatments and cutting-edge cancer therapies that help a child's immune system defeat cancer, and made other major contributions to pediatric medicine.
Researchers work in close collaboration with one another, their colleagues at partner institutions including the University of Washington and Fred Hutch and our healthcare providers at Seattle Children's Hospital, one of U.S. News & World Report’s top children's hospitals. This collaboration is one of our key strengths, allowing our faculty to draw on a variety of disciplines and techniques as they pursue solutions to some of medicine's most complex problems.
We are committed to not only treating disease but to eliminating it. Help us achieve our vision of being a worldwide leader in pediatric research aimed to improve the health and well-being of children. If you are interested in a challenging career aimed at groundbreaking research, Seattle Children's Research Institute is the place for you.
Our Commitment
Seattle Children’s welcomes people of all experiences, backgrounds, and thoughts as this is what drives our spirit of inquiry and allows us to better connect with our patients and families. Our organization recruits, employs, trains, compensates, and promotes based on merit without regard to race, religion, color, national origin, gender (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, status as a protected veteran, status as an individual with a disability, or other applicable legally protected characteristics.
The people who work at Seattle Children’s are members of a community that seeks to respect and celebrate all the qualities that make each of us unique. Each of us is empowered to be ourselves.
Seattle Children’s is proud to be an Equal Opportunity Workplace and Affirmative Action Employer.
The Heczey Lab believes that the development of the next-generation of cell therapies will be based on in-vivo (inside the body) genetic engineering of cells which can overcome the immune escape mechanisms employed within the tumor microenvironment to safely and effectively cure patients with cancer. The lab has a preclinical and clinical arm.
The post-doctoral associate will be part of an energetic team within the combined translational laboratories of the Ben Towne Center for Childhood Cancer and Blood Disorders Research at the Seattle Children’s Research Institution.
The post-doctoral associate will be tasked to design and conduct the experiments related to the project with the help of the mentor and other team members of the Heczey Lab. He/she will analyze the data and present the evolving results at weekly laboratory meetings and research seminars of the Seattle Children’s Research Institution. The details of the experiments and the findings will be recorded in electronic laboratory notebook.
Required Education and Experience
Doctorate degree (PhD/DVM/MD) in Immunology, genetic engineering, or related fields.
Experience using basic research techniques of specialty area.
Required Credentials: PhD
Preferred:
Great fund of knowledge of tumor immunology principles.
Understanding advanced genetic engineering techniques (transfection, retroviral / lentiviral transduction, transposition, CRISPR-Cas9).
Viral particle assembly.
Advanced cloning methods
Expertise in functional characterization of CAR T cells
Excellent aseptic cell culture technique.
Enthusiasm and a willingness to learn in a fast-pace, collaborative environment.
Strong organizational skills, record keeping, and interpersonal communication skills (verbal and written).
Compensation Range
$80,172/year
Salary Information: This compensation range was calculated based on full-time employment (2080 hours worked per calendar year). Offers are determined by multiple factors including equity, skills, experience, and expertise, and may vary within the range provided.
Benefits Information: Seattle Children’s offers a generous benefit package, including medical, dental, and vision plans, 403(b), life insurance, paid time off, tuition reimbursement, and more. Additional details on our benefits can be found on our website www.seattlechildrens.org/careers/benefits.
About Us
Hope. Care. Cure. These three simple words capture what we do at Seattle Children’s – to help every child live the healthiest and most fulfilling life possible. Are you ready to engage with a mission-driven organization that is life-changing to many, and touches the hearts of all? #HOPECARECURE
As one of the nation's top five pediatric research centers, Seattle Children's Research Institute is dedicated to providing hope, care, and cures to help every child live the healthiest and most fulfilling life possible.
Our investigators are involved in hundreds of projects that cover every phase of research, from studying how diseases work to improving investigational therapies. They have pioneered groundbreaking cystic fibrosis treatments and cutting-edge cancer therapies that help a child's immune system defeat cancer, and made other major contributions to pediatric medicine.
Researchers work in close collaboration with one another, their colleagues at partner institutions including the University of Washington and Fred Hutch and our healthcare providers at Seattle Children's Hospital, one of U.S. News & World Report’s top children's hospitals. This collaboration is one of our key strengths, allowing our faculty to draw on a variety of disciplines and techniques as they pursue solutions to some of medicine's most complex problems.
We are committed to not only treating disease but to eliminating it. Help us achieve our vision of being a worldwide leader in pediatric research aimed to improve the health and well-being of children. If you are interested in a challenging career aimed at groundbreaking research, Seattle Children's Research Institute is the place for you.
Our Commitment
Seattle Children’s welcomes people of all experiences, backgrounds, and thoughts as this is what drives our spirit of inquiry and allows us to better connect with our patients and families. Our organization recruits, employs, trains, compensates, and promotes based on merit without regard to race, religion, color, national origin, gender (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, gender expression, age, status as a protected veteran, status as an individual with a disability, or other applicable legally protected characteristics.
The people who work at Seattle Children’s are members of a community that seeks to respect and celebrate all the qualities that make each of us unique. Each of us is empowered to be ourselves.
Seattle Children’s is proud to be an Equal Opportunity Workplace and Affirmative Action Employer.
