Postdoctoral Associate - LC-MS-based Omics
- Baylor College of Medicine
- Location: Houston, TX
- Job Number: 7369302 (Ref #: 26107-en_US)
- Posting Date: Newly posted
Job Description
Summary
The Center for Drug Discovery ( https://www.bcm.edu/research/centers/drug-discovery) is a strategic research center at Baylor College of Medicine in Houston, Texas. The lab is looking for a highly self-motivated Postdoctoral Research Associate with extensive experience in liquid chromatography–mass spectrometry (LC–MS) metabolomics, lipidomics, and drug metabolism. The Postdoctoral Associate will apply advanced MS-based approaches to study the proteosome and metabolome to characterize our newly created dTAG-KI animal models and conduct the drug metabolism pharmacokinetics studies. The lab is well-equipped with Thermos UHPLC-Q Exactive MS, Orbitrap Exploris™ 120, Thermo Quintus (triple quadruple), and Imaging mass spectrometry (IMS, Bruker timsTOF fleX MALDI-2). The position provides opportunities for advanced training in mass spectrometry, metabolomics, lipidomics, drug metabolism, toxicology, and imaging mass spectrometry within a collaborative and multidisciplinary research environment.
Baylor College of Medicine typically follows similar to the NIH stipulated stipend guidelines for Postdoctoral Associates.
Job Duties
- Develops, optimizes, and validates LC–MS and LC–MS/MS methods for metabolomics, lipidomics, drug metabolism, and biomarker analysis.
- Performs sample preparation and extraction of metabolites, lipids, drugs, and drug metabolites from cells, tissues, plasma, and other biological matrices.
- Conducts untargeted and targeted metabolomics and lipidomics studies.
- Processes, analyzes, interprets, and visualizes complex mass spectrometry datasets using appropriate computational and statistical tools.
- Performs in vitro drug-metabolism studies that includes incubations with liver microsomes, primary human hepatocytes, and other relevant biological systems.
- Identifies and characterizes drug metabolites using high-resolution mass spectrometry and tandem mass spectrometry.
- Assesses cellular toxicity using biochemical, molecular, imaging, and metabolomics-based endpoints.
- Maintains accurate experimental records and contributes to data interpretation, scientific presentations and manuscripts.
- Performs other job-related duties as assigned.
Minimum Qualifications
- MD or Ph.D. in Basic Science, Health Science, or a related field.
- No experience required.
Preferred Qualifications
- PhD or equivalent doctoral degree in analytical chemistry, pharmacology, pharmaceutical sciences, biochemistry, metabolomics, or a related discipline.
- Demonstrated expertise in metabolomics and/or lipidomics, including sample preparation, instrument operation, data processing, and biological interpretation.
- Experience with high-resolution LC–MS platforms, especially Thermo Orbitrap Exploris MS.
- Proficiency with metabolomics and lipidomics data-analysis software and multivariate statistical methods.
- Experience with primary human hepatocytes or other physiologically relevant cell models.
- Experience with imaging mass spectrometry, including MALDI or DESI imaging, would be a significant advantage.
- Experience with mammalian cell culture and drug-induced toxicity studies.
- Strong publication record in mass spectrometry, metabolomics, lipidomics, drug metabolism, toxicology, or related fields.
- Strong organizational, analytical, troubleshooting, and scientific communication skills.
Baylor College of Medicine fosters diversity among its students, trainees, faculty and staff as a prerequisite to accomplishing our institutional mission, and setting standards for excellence in training healthcare providers and biomedical scientists, promoting scientific innovation, and providing patient-centered care. - Diversity, respect, and inclusiveness create an environment that is conducive to academic excellence, and strengthens our institution by increasing talent, encouraging creativity, and ensuring a broader perspective. - Diversity helps position Baylor to reduce disparities in health and healthcare access and to better address the needs of the community we serve. - Baylor is committed to recruiting and retaining outstanding students, trainees, faculty and staff from diverse backgrounds by providing a welcoming, supportive learning environment for all members of the Baylor community.
